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Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity


Mandić, Leo; Mlinarić-Majerski, Kata; Basarić, Nikola
Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity // MACROCYCLES - synthesis, medicinal chemistry and biological activity
Zagreb, 2014. (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Photochemical synthesis of medium and large aza-heterocyclic compounds with potential biological activity

Autori
Mandić, Leo ; Mlinarić-Majerski, Kata ; Basarić, Nikola

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
MACROCYCLES - synthesis, medicinal chemistry and biological activity / - Zagreb, 2014

Skup
MACROCYCLES - synthesis, medicinal chemistry and biological activity

Mjesto i datum
Zagreb, Hravtska, 28-29-04-2014

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Adamantanes; benzazepines; photochemistry; biological activity

Sažetak
Various aza-heterocyclic compounds show biological activity. For example, pyrrolo[1, 4]benzodiazepines show highly selective binding to DNA.1 Likewise, benzazepine skeleton is a part of numerous biologically active compounds.2 Furthermore, adamantane is a very important pharmacophore that has been found in different classes of biologically active compounds.3 Therefore, it is necessary to develop new synthetic methods for the preparation of new functionalized adamantyl-heterocyclic derivatives. With the ongoing interest in our group to apply photochemical approach to the synthesis of adamantyl-heterocyclic derivatives with biological applications, 4 we have functionalized adamantanes by the phthalimide group, versatile chromophore that undergoes various photochemical reactions. Herein we describe synthesis of novel (N-phthalimido)adamantane carboxylic acid 1 and its efficient one-pot transformation to complex heterocyclic compound, adamantyl benzazepine 2, with anticipated biological activity, that is yet to be tested.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
02.05/25
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Kata Majerski, )

Ustanove
Institut "Ruđer Bošković", Zagreb