engleski

Microvessel quantitation in synovium

Rheumathoid arthritis (RA) is characterized by joint inflammation which results from the tumor-like proliferation of synovial cells as a pannus overlaying and destroying cartilage and bone. The formation of new blood vessels (angiogenesis) is critical in this proces. The aim of this study was to analyze the relationship between the microvessel density, detected by immunohistochemical analysis using FVIII antigen and proliferative activity of synovial cells determined by nucleolar organizer regions (AgNOR) in three different synovial disease (RA, bacterial arthitis/BA and osteoarthritis/OA). The microvessel count (the mean number of microvessels in the three areas of highest vascular density at x200 magnification) was significantly hihger in patients with RA (79.8+30.3) and BA (68.9+37.7) than in those with diagnosis of OA (46.5+21.5) (p<0.05) while the AgNOR parameters was highest in synovial cells of RA (5.5+2.5) than in BA (3.8+1.9) and OA (3.4+2.1) (p<0.0001). These preliminary results indicate that vascular proliferation in bacterial arthritis is not accompanied by activation of proliferative markers of synovial cells. In other words sign of increased synoviocytes proliferation apperead to be typical for rheumatoid arhtitis.

nije evidentirano

nije evidentirano