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New Insights into the Role of Chronic Inflammation and Cytokines in Etiopathogenesis of GEP-NETs


Cigrovski Berković, Maja; Čačev, Tamara; Catela Ivković, Tina; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
New Insights into the Role of Chronic Inflammation and Cytokines in Etiopathogenesis of GEP-NETs // Neuroendocrinology, 99 (2014), 75-84 doi:10.1159/000362339 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
New Insights into the Role of Chronic Inflammation and Cytokines in Etiopathogenesis of GEP-NETs

Autori
Cigrovski Berković, Maja ; Čačev, Tamara ; Catela Ivković, Tina ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Izvornik
Neuroendocrinology (0028-3835) 99 (2014); 75-84

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
GEP-NET; inflammation; cytokines; tumorigenesis

Sažetak
Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100, 000) and prevalence (35/100, 000) of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NETs molecular biology, there is still little advance in the early diagnosis due to lack of specific tumour markers. As the tumours are mostly detected in their late stage, they are not well controlled by either biotherapy or conventional chemotherapy, and thus represent a significant clinical issue. Chronic inflammation has been implicated in the development of GEP-NETs. This review presents recent findings that link pro- inflammatory cytokines to molecular basis of GEP- NETs tumorigenesis, leading to a more personalized approach to disease management and therapy.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
098-0982464-2508 - Molekularna genetika i farmakogenetika gastrointestinalnih tumora (Sanja Kapitanović, )
134-1342428-0491 - Neuroendokrini tumori probavnog sustava i gušterače (Maja Cigrovski Berković, )

Ustanove
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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