New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors (CROSBI ID 204922)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Cigrovski Berković, Maja ; Čačev, Tamara ; Catela Ivković, Tina ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja
engleski
New insights into the role of chronic inflammation and cytokines in the etiopathogenesis of gastroenteropancreatic neuroendocrine tumors
Although previously considered rare, recent epidemiological studies have revealed that the incidence (3.6/100, 000) and prevalence (35/100, 000) of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has increased over the past few decades. Despite the progress in the understanding of GEP-NETs molecular biology, there is still little advance in the early diagnosis due to lack of specific tumour markers. As the tumours are mostly detected in their late stage, they are not well controlled by either biotherapy or conventional chemotherapy, and thus represent a significant clinical issue. Chronic inflammation has been implicated in the development of GEP-NETs. This review presents recent findings that link pro- inflammatory cytokines to molecular basis of GEP- NETs tumorigenesis, leading to a more personalized approach to disease management and therapy.
GEP-NET ; inflammation ; cytokines ; tumorigenesis
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Podaci o izdanju
Povezanost rada
Kliničke medicinske znanosti, Temeljne medicinske znanosti