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Pregled bibliografske jedinice broj: 692565

Visfatin is Not Associated with Inflammatory Markers in Patients on Hemodialysis


Ćelap, Ivana; Šimundić, Ana-Maria; Nikolac, Nora; Miler, Marijana; Zec, Ivana; Altabas, Karmela; Šefer, Siniša
Visfatin is Not Associated with Inflammatory Markers in Patients on Hemodialysis // Clinical laboratory (Heidelberg. 1996), 59 (2013), 11-12; 1253-1259 doi:10.7754/Clin.Lab.2013.121036 (međunarodna recenzija, članak, znanstveni)


Naslov
Visfatin is Not Associated with Inflammatory Markers in Patients on Hemodialysis
(Visfatin is not associated with inflammatory markers in patients on hemodialysis)

Autori
Ćelap, Ivana ; Šimundić, Ana-Maria ; Nikolac, Nora ; Miler, Marijana ; Zec, Ivana ; Altabas, Karmela ; Šefer, Siniša

Izvornik
Clinical laboratory (Heidelberg. 1996) (1433-6510) 59 (2013), 11-12; 1253-1259

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Endothelial dysfunction ; fibrinogen ; hemodialysis ; inflammation ; PAI-1 ; visfatin

Sažetak
Cardiovascular events are a major cause of death in patients with end-stage renal disease. Endothelial dysfunction represents a key event in atherosclerosis development and has been implicated in the pathophysiology of different forms of cardiovascular disease, including chronic kidney disease. In recent years, visfatin, a ubiquitous adipokine, has been described as a potent marker of endothelial inflammation and dysfunction. The aim of the study was to investigate the association of visfatin with well-known markers of inflammation and endothelial dysfunction. Serum and plasma samples from 66 patients (40 males and 26 females) treated by hemodialysis were analysed for visfatin, fibrinogen, CRP, PAI-1 levels. Visfatin was determined by ELISA method while CRP, fibrinogen and PAI-1 were obtained by standard laboratory methods. We observed statistically significant correlation between visfatin level and fibrinogen (r = 0.51 ; p = 0.008) and the time on dialysis in female patients (r = 0.70 ; p  0.001). PAI-1 and CRP did not correlate with visfatin in males nor in females. Conclusions: Visfatin is correlated with time on dialysis and with fibrinogen only in female dialysis patients. To confirm this, further studies are needed with a higher number of patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
(Zapis je netocan (?) - rada pod navedenim naslovom (+ autor) nema u CC-u niti WoS-u ; naslov casopisa i numericki podaci (?) ; admin 2015-09-04.) pronadjen u bazama 3.3.2017. admin



POVEZANOST RADA


Projekt / tema
134-1340227-0200 - Upala i udio farmakogenetike u razvoju i ishodu akutnih i kroničnih bolesti (Ana-Maria Šimundić, )

Ustanove
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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