engleski

Epicardial adipose tissue thickne ss as predictor for adiponectin systemic blood concentration

INTRODUCTION: Epicardial adipose tissue (E AT) is a known risk factor for CAD and metabolic syndrome. Adiponectin (ADIPOQ) is responsible for the modulation of metabolic syndrome. Also, ADI POQ exerts its antiatherogen ic effects on the vascular endothelium. The aim of this study is to predict possible concentrations of ADIPOQ, IL6 and TNFa in the aortic root (AR) and coronary sinus (CS) using EAT thickness. METHODS: In this study 34 subject were in cluded, 16 with CAD an d 20 controls all of whom underwent cardiosurgery. Prior to card iosurgery, EAT thic kness was measured by echocardiography and coronarography wa s performed in all subjects. During cardiosurgery, blood samples were taken from AR and CS. ADI POQ, IL6 and TNFa concentrations were measured in the AR and CS. RESULTS: EAT thickness is po sitively correlated with IL6CS concentration (r = 0.418, p = 0.024) and negatively correlated with ADIPOQAR (r = -0.6 25, p < 0.001) and ADIPOQCS (r = -0.631, p < 0.001). EAT thickn ess did not show correlation with TNFa concentration in AR or CS. MARS analysis showed that ADIPOQAR (R2 = 0.529) and ADIPOQCS (R2 = 0.539) concen tration can be predicted w ith EAT thickness. Also, MARS analysis showed that IL6CS concentra tion can be predicted (R2 = 0.159) but with very low accuracy. CONCLUSION: EAT thickness, known CAD risk factor, is positivel y correlated with IL6CS concentration, wh ich indicates that ticker EAT is producing more proinflamatory cytokines. Also, EAT thickness is ne gatively correlated with ADIPOQAR and ADIPOQCS. EAT thickness can be used, fairly accurately as predic tor for adiponectin systemic concentration. KEYWORDS: adipse tissue, adip onectin, concentration, interleukin 6, tumor necrosis factor alpha

dipse tissue; adip onectin; concentration; interleukin 6; tumor necrosis factor alpha

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