engleski

Association between ABO blood group, Rh factor and breast cancer in patients treated at the University hospital for Tumors, Zagreb, Croatia

The study is a retrospective review of 407 female patients with primary breast cancer and 320 female patients with benign breast changes who were surgically treated in the University Hospital for Tumors during calendar year 2009. We investigated a possible link between the ABO blood group and breast cancer. All patients had their blood group (ABO antigen and RhD) determined, as a part of preoperative treatment, at the Department for Tranfusion Medicine of the Universiti Hospital for Tumors. Erythrocyte antigens were determined using the plate and microcard technique. The mean age of all patients was 62.1 years (range 30-95yrs). No statistically significant differences were found between patients who have cancer and those who have not in the frequency of certain blood groups. Also, there was no statistically significant difference between patients with cancer and those without cancer in the frequency of Rh (p=0, 076). We found a statistically significant but slight correlation between Rh factor and HER2/neu (p=0, 038). According to the correlation coefficient, the correlation between these two variables in none or slight. The causal relationship between the two parameters remains unknown and should be tested in larger study.

ABO blood groups; Rh factor; breast cancer; HER2/neu

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