engleski

a-[11C] methyl-L tryptophan-PET as a surrogate for interictal cerebral serotonin synthesis in migraine without aura

Alteration in central serotonin biology has been implicated in migraine, and serotonin (5-HT) agonists have been available for more than a decade in the treatment of that condition. Objectives were to test this hypothesis, we studied in vivo using positron-emission tomography (PET) and a -[ 11 C] methyl- L-tryptophan ( a -[ 11 C]MTrp) as a surrogate marker of cerebral 5-HT synthetic rate before and after administration of eletriptan in migraine and control subjects. Six nonmenopausal female migraine subjects with migraine without aura (MoA) and six nonmenopausal age- matched female control subjects were scanned at baseline and after oral administration of 40mg of eletriptan. Migraine subjects at the time of PET had to have been headache free for a minimum of three days. Images of ( a -[ 11 C]MTrp) brain trapping were colocalized with individual MRI images in three dimensions and analyzed. There was no difference in baseline cerebral global 5-HT synthesis between migraine and control subjects. After administration of eletriptan, there was a striking global reduction in cerebral 5-HT synthesis (K*) in the migraine group and in 22 regions of interest (ROIs). In control subjects, no significant changes were found in global cerebral 5-HT synthesis (K*) or in any of the ROIs. These findings suggest in migraine an interictal alteration in the regulation mechanisms of cerebral 5-HT synthesis.

migraine ; PET ; cerebral serotonin ; eletriptan

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