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Pregled bibliografske jedinice broj: 684038

Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone-macrolide combination


Magri, V.; Marras, E.; Škerk, Višnja; Markotić, Alemka; Restelli, A.; Garlaschi, M.C.; Perletti, G.
Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone-macrolide combination // Andrologia (Berlin), 42 (2010), 6; 366-375 doi:10.1111/j.1439-0272.2009.01033.x (međunarodna recenzija, članak, znanstveni)


Naslov
Eradication of Chlamydia trachomatis parallels symptom regression in chronic bacterial prostatitis patients treated with a fluoroquinolone-macrolide combination

Autori
Magri, V. ; Marras, E. ; Škerk, Višnja ; Markotić, Alemka ; Restelli, A. ; Garlaschi, M.C. ; Perletti, G.

Izvornik
Andrologia (Berlin) (0303-4569) 42 (2010), 6; 366-375

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chlamydia trachomatis; bacterial prostatitis; fluoroquinolone-macrolide combination

Sažetak
To investigate the association between eradication of (CT) and symptom regression in chronic prostatitis, 55 symptomatic patients were subjected to segmented tests to localise CT in first voided urine (VB1), prostatic secretions (EPS), post-massage voided (VB3) or semen specimens. Patients were divided in three treatment groups: the 'urethral involvement' group ('U': VB1 positive, EPS/VB3/Semen negative) was treated with 500 mg day(-1) azithromycin for 3 days. The 'prostatitis' group ('P': VB1 negative, EPS/VB3/semen positive) with 4-week levofloxacin-azithromycin combination. A third group, 'U+P' (VB1, EPS/VB3/semen positive) received both treatments in sequence. In P patients, eradication of CT was paralleled by marked, sustained symptom improvement and by significant decrease of serum prostate-specific antigen (PSA) levels. Compared with U patients, undergoing rapid regression of symptoms related to painful micturition after short-term azithromycin, U+P patients showed symptom and pathogen persistence in VB3/EPS/semen and required additional treatment with 4-week levofloxacin-azithromycin to achieve pathogen eradication, symptom regression, and decrease of PSA. Our results support a causative role of CT in chronic bacterial prostatitis. In the presence of a positive urethral localisation of the pathogen, thorough microbiological investigation together with focused symptom analysis may reveal an underlying chlamydial prostatitis and direct effective therapy with appropriate antibacterial agents.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
143-1080002-0050 - Dijagnostika i liječenje bolesnika sa sindromom prostatitisa (Višnja Škerk, )
143-1430115-0103 - Imunoreakcije na hantaviruse i leptospire (Alemka Markotić, )

Ustanove
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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