Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder (CROSBI ID 202917)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Božina, Nada ; Mihaljević Peleš, Alma ; Šagud, Marina ; Bilusić, Hrvoje ; Jakovljević, Miro
engleski
Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder
We investigated the relationships between LS promoter (SERTPR) and ls intron2 (SERTin2) genetic variants of serotonin transporter (SERT) polymorphisms with treatment response in 130 patients with major depressive disorder (MDD) treated with paroxetine (20 mg/day) for 6 weeks. To assess and evaluate therapeutic response to paroxetine all patients were rated weekly using the HAMD-17 scale. Responders were defined as those subjects with a decrease in HAMD scale by50% at week 6 of treatment. Comparison of genotypes and alleles frequency of the SERTPR between responders and non-responders revealed significant differences among genotypes and overrepresentation of the S allele in the group of non-responders (P=0.0004). SERTin2-ss genotype bearing subjects showed better treatment response compared to ls and ll genotype from the fourth week of treatment (P=0.035). Statistical differences were also found in distributions of the estimated haplotypes between responders and non-responders, while subsequent analysis revealed overrepresentation of S/l haplotype (P=0.006) in the group of non- responders. SERTPR and SERTin2 were found to be in linkage disequilibrium in studied population. These findings identify genetic factors associated with paroxetine treatment response in MDD patients.
paroxetine; major depressive disorder; genetics; serotonin transporter; treatment
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
9 (3)
2008.
190-197
objavljeno
1562-2975
10.1080/15622970701308397
Povezanost rada
Kliničke medicinske znanosti