Arylsulphatase A(ASA) in human brain during ageing (CROSBI ID 480622)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Radeljak, Sanja ; Mihaljević-Peleš Alma
engleski
Arylsulphatase A(ASA) in human brain during ageing
A relationship between arylsulphatase A(ASA) deficiency and various neuropsychiatric disorders has been indicated. However, very little is known about regional distribution and ASA activity in human brain during ageing. Thus, we measured ASA activity in different brain regions(prefrontal, parietal, temporal, occipital, cerebellar, hypoccampal and insular cortex, sensorymotor cortex, talamus and amigdala) of healthx persons, using para-nitro.catechol(p-NCS) as an in vitro substrate. In the "younger" group(age 15-30), ASA activity was highest in cerebellar and lowest in sensorymotor cortex. There was no correlation between ASA activity and in any of the region and age. In the "older" group(30-80 years), ASA activity was decreased in occipital(by 10%) and cerebellar(by 30%)cortex, and stable in in fronatal cortex and other region irrespective of age. Our results suggest that ASA activity in selected brain regions declines during ageing. Since ASA defficiency is related to demyelinization process and ASA pseudodefficiency has high rate among general population, one could assume that the age-related decline in ASA activity might contribute to onset of demyelinization-associated neuropsychiatric disorders on elderly.
ASA; human brain; ageing
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o prilogu
177-177.-x.
1998.
objavljeno
Podaci o matičnoj publikaciji
Psychiatria Danubina
Hofmann, Gustav ; Sartorius, Norman
Zagreb: Medicinska naklada
Podaci o skupu
18th Danube Symposium of Psychiatry
poster
04.06.1998-06.06.1998
nije evidentirano