Glucose reduces alloxan induced alterations of nociception (CROSBI ID 480591)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Šalković-Petrišić, Melita ; Lacković, Zdravko
engleski
Glucose reduces alloxan induced alterations of nociception
According to literature data, alloxan-induced betacytotoxic effects can be prevented by prior glucose administration. We investigated the effects of peripheral (intraperitoneal/ip) and central (intracerebroventricular/icv) 0.1 M and 1 M glucose-15 min pretreatment on centrally (icv) applied alloxan (1000 ug/kg)-induced alterations of nociception, dtetermined by the 'hot-plate' and 'tail immersion' tests. Alloxan icv treatment alone induced bradual increase (</= 100% over control) of pain treshold in both tests in the course of a 3 week posttreatment period. Similar increment of pain treshold was induced by a glucose (ip/icv) treatment alone, as well. Glucose pretreatment, in general, reduced alloxan induced increase of pain treshold in both tests. However, the effect was more consistent, pronounced with higher glucose dose (in the hot test plate even reversed to control values) and could be seen as early as 1 week following glucose icv (vs. 3 weeks following glucose ip pretreatment). It seems that glucose 15 min-pretreatment reduces alloxan icv-induced alterations of pain treshold, with glucose icv preptreatment being more successful than glucose ip pretreatment.
alloxan; glucose; nociception
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Podaci o prilogu
177-x.
1999.
objavljeno
Podaci o matičnoj publikaciji
Fundamental&Clinical Pharmacology 1999; vol. 13, Suppl 1
Guidicelli, Jean-Francois
Pariz: Elsevier
Podaci o skupu
2nd European Congress Of Pharmacology
poster
03.07.1999-07.07.1999
Budimpešta, Mađarska