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Pregled bibliografske jedinice broj: 680621

Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases


Markeljević, Jasenka; Batinić, Drago; Užarević, Branka; Božikov, Jadranka; Čikes, Nada; Babić- Naglić, Đurđica; Horvat, Zvonimir; Marušić, Matko.
Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases // Journal of rheumatology. Supplement, 21 (1994), 12; 2225-2230 (međunarodna recenzija, članak, znanstveni)


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Naslov
Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases

Autori
Markeljević, Jasenka ; Batinić, Drago ; Užarević, Branka ; Božikov, Jadranka ; Čikes, Nada ; Babić- Naglić, Đurđica ; Horvat, Zvonimir ; Marušić, Matko.

Izvornik
Journal of rheumatology. Supplement (0380-0903) 21 (1994), 12; 2225-2230

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
peripheral blood B cells; systemic connective tissue diseases
(peripheral blood B cells; connective tissue diseases)

Sažetak
OBJECTIVE: To get a better insight into the level of circulating CD5+ B cells as related to the systemic connective tissue disease activity. METHODS: Peripheral blood CD5+CD19+ cells of patients in the remission phase of systemic lupus erythematosus (SLE) (n = 28), Sjögren's syndrome (SS) (n = 20), rheumatoid arthritis (RA) (n = 26), and 19 control healthy subjects were analyzed by 2-color flow cytometry. RESULTS: In comparison to control group, the patients with SLE had a significant increase in the relative CD19+CD5+ blood cell count (p < 0.0005) ; this count was also different from the finding in both RA (p < 0.005) and patients with SS (p < 0.05). In contrast, the proportion of B cells expressing CD5 (within an individual B cell population) was significantly increased in all the 3 diseases compared to healthy subjects (SLE, p < 0.0001 ; SS, p < 0.05 ; and RA, p < 0.01). In the multivariate discriminant analysis, a discriminant function defined by the CD19+CD5+ subset strongly discriminated SLE, SS and RA from the control, but also SLE from both SS and RA. CONCLUSION: objective: Our findings demonstrated that, in relation to healthy control subjects, the blood CD5+ B subset tended to be elevated in the patients in the remission phase of systemic connective tissue diseases, particularly in SLE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Markeljević, Jasenka; Batinić, Drago; Užarević, Branka; Božikov, Jadranka; Čikes, Nada; Babić- Naglić, Đurđica; Horvat, Zvonimir; Marušić, Matko.
Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases // Journal of rheumatology. Supplement, 21 (1994), 12; 2225-2230 (međunarodna recenzija, članak, znanstveni)
Markeljević, J., Batinić, D., Užarević, B., Božikov, J., Čikes, N., Babić- Naglić, Đ., Horvat, Z. & Marušić, M. (1994) Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases. Journal of rheumatology. Supplement, 21 (12), 2225-2230.
@article{article, year = {1994}, pages = {2225-2230}, keywords = {peripheral blood B cells, systemic connective tissue diseases}, journal = {Journal of rheumatology. Supplement}, volume = {21}, number = {12}, issn = {0380-0903}, title = {Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases}, keyword = {peripheral blood B cells, systemic connective tissue diseases} }
@article{article, year = {1994}, pages = {2225-2230}, keywords = {peripheral blood B cells, connective tissue diseases}, journal = {Journal of rheumatology. Supplement}, volume = {21}, number = {12}, issn = {0380-0903}, title = {Peripheral blood CD5+ B cell subset in the remission phase of systemic connective tissue diseases}, keyword = {peripheral blood B cells, connective tissue diseases} }

Časopis indeksira:


  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • PMID: 7535356 [PubMed - indexed for MEDLINE]





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