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Pregled bibliografske jedinice broj: 680516

Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants


Božina, Nada; Jovanović, Nikolina; Podlesek, Anja; Rojnić Kuzman, Martina; Kudumija Slijepčević, Marija; Roguljić, Ante; Dimitrović, A.; Božina, Tamara; Lovrić, Jasna; Ljubić, Hana; Medved, Vesna
Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants // Journal of psychiatric research, 46 (2012), 6; 767-773 doi:10.1016/j.jpsychires.2012.03.008 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 680516 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants

Autori
Božina, Nada ; Jovanović, Nikolina ; Podlesek, Anja ; Rojnić Kuzman, Martina ; Kudumija Slijepčević, Marija ; Roguljić, Ante ; Dimitrović, A. ; Božina, Tamara ; Lovrić, Jasna ; Ljubić, Hana ; Medved, Vesna

Izvornik
Journal of psychiatric research (0022-3956) 46 (2012), 6; 767-773

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
suicide ideation ; suicide attempt ; schizophrenia ; serotonin transporter ; polymorphism ; 5-HTTLPR ; rs25531 ; haplotype

Sažetak
Aim was to examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5- HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). RESULTS: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores ; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G) ; 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants ; 4) Subjects with 5- HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G, )SL(A)) scored higher on the PANSS general psychopathology subscale ; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5- HTTLPR/rs25531/In2 haplotype distribution. The suicide ideators, attempters and controls did not differ significantly in 5- HTTLPR or 5-HTT VNTR In 2 variants, but 5- HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-1081874-2416 - Sjögrenov sindrom - neurohumoralna regulacija autoimunosti i aterogeneza (Markeljević, Jasenka, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Božina, Nada; Jovanović, Nikolina; Podlesek, Anja; Rojnić Kuzman, Martina; Kudumija Slijepčević, Marija; Roguljić, Ante; Dimitrović, A.; Božina, Tamara; Lovrić, Jasna; Ljubić, Hana; Medved, Vesna
Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants // Journal of psychiatric research, 46 (2012), 6; 767-773 doi:10.1016/j.jpsychires.2012.03.008 (međunarodna recenzija, članak, znanstveni)
Božina, N., Jovanović, N., Podlesek, A., Rojnić Kuzman, M., Kudumija Slijepčević, M., Roguljić, A., Dimitrović, A., Božina, T., Lovrić, J., Ljubić, H. & Medved, V. (2012) Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants. Journal of psychiatric research, 46 (6), 767-773 doi:10.1016/j.jpsychires.2012.03.008.
@article{article, author = {Bo\v{z}ina, Nada and Jovanovi\'{c}, Nikolina and Podlesek, Anja and Rojni\'{c} Kuzman, Martina and Kudumija Slijep\v{c}evi\'{c}, Marija and Rogulji\'{c}, Ante and Dimitrovi\'{c}, A. and Bo\v{z}ina, Tamara and Lovri\'{c}, Jasna and Ljubi\'{c}, Hana and Medved, Vesna}, year = {2012}, pages = {767-773}, DOI = {10.1016/j.jpsychires.2012.03.008}, keywords = {suicide ideation, suicide attempt, schizophrenia, serotonin transporter, polymorphism, 5-HTTLPR, rs25531, haplotype}, journal = {Journal of psychiatric research}, doi = {10.1016/j.jpsychires.2012.03.008}, volume = {46}, number = {6}, issn = {0022-3956}, title = {Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants}, keyword = {suicide ideation, suicide attempt, schizophrenia, serotonin transporter, polymorphism, 5-HTTLPR, rs25531, haplotype} }
@article{article, author = {Bo\v{z}ina, Nada and Jovanovi\'{c}, Nikolina and Podlesek, Anja and Rojni\'{c} Kuzman, Martina and Kudumija Slijep\v{c}evi\'{c}, Marija and Rogulji\'{c}, Ante and Dimitrovi\'{c}, A. and Bo\v{z}ina, Tamara and Lovri\'{c}, Jasna and Ljubi\'{c}, Hana and Medved, Vesna}, year = {2012}, pages = {767-773}, DOI = {10.1016/j.jpsychires.2012.03.008}, keywords = {suicide ideation, suicide attempt, schizophrenia, serotonin transporter, polymorphism, 5-HTTLPR, rs25531, haplotype}, journal = {Journal of psychiatric research}, doi = {10.1016/j.jpsychires.2012.03.008}, volume = {46}, number = {6}, issn = {0022-3956}, title = {Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants}, keyword = {suicide ideation, suicide attempt, schizophrenia, serotonin transporter, polymorphism, 5-HTTLPR, rs25531, haplotype} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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