engleski

Suicide ideators and attempters with schizophrenia - The role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants

Aim was to examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour. The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5- HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS). RESULTS: Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184). Major findings: 1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores ; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G) ; 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants ; 4) Subjects with 5- HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G, )SL(A)) scored higher on the PANSS general psychopathology subscale ; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5- HTTLPR/rs25531/In2 haplotype distribution. The suicide ideators, attempters and controls did not differ significantly in 5- HTTLPR or 5-HTT VNTR In 2 variants, but 5- HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.

suicide ideation ; suicide attempt ; schizophrenia ; serotonin transporter ; polymorphism ; 5-HTTLPR ; rs25531 ; haplotype

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