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CTLA-4 +49 and TNF-alfa-308 Gene Polymorphisms in Celiac Patients with Exocrine Pancreatic Insufficiency


Licul, Vanja; Starčević Čizmarević, Nada; Ristić, Smiljana; Mikolašević, Ivana; Mijandrušić Sinčić, Brankica
CTLA-4 +49 and TNF-alfa-308 Gene Polymorphisms in Celiac Patients with Exocrine Pancreatic Insufficiency // Collegium antropologicum, 37 (2013), 4; 1191-1194 (međunarodna recenzija, članak, znanstveni)


Naslov
CTLA-4 +49 and TNF-alfa-308 Gene Polymorphisms in Celiac Patients with Exocrine Pancreatic Insufficiency
(CTLA-4+49 and TNF-alpha-308 Gene Polymorphisms in Celiac Patients with Exocrine Pancreatic Insufficiency)

Autori
Licul, Vanja ; Starčević Čizmarević, Nada ; Ristić, Smiljana ; Mikolašević, Ivana ; Mijandrušić Sinčić, Brankica

Izvornik
Collegium antropologicum (0350-6134) 37 (2013), 4; 1191-1194

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Celiac disease ; exocrine pancreatic insufficiency ; gene polymorphism

Sažetak
Celiac disease (CD) is a life-long gluten sensitive autoimmune disease of the small intestine affecting genetically susceptible individuals. Human leukocyte antigen (HLA) genotype contributes to the genetic risk for CD, but “non-HLA” genes also play a role. Clinical presentation could be classical, but majority of patients present with non-classical, atypical signs and symptoms. Endocrine and/or exocrine pancreatic insufficiency (EXPI) is common in celiac patients. The aim of our study was to assess EXPI among our CD patients by measurement of faecal pancreatic elastase (FE1) and to find potential association of CTLA-4 +49 and TNF-a-308 gene polymorphism and EXPI. Eighty three patients entered the study. Tissue transglutaminase antibodies (anti-TTG), faecal elastase-1 (FE1) assays and genotyping for the CTLA-4 +49 A⁄G and TNF-a308 were performed. Of 83 patients with CD EXPI had 13 (15, 6%). There was no statistically significant difference in frequency of polymorphisms for both genes (CTL-4 +49 i TNF-a-308) in the group with and without EXPI. In conclusion, EXPI is common in symptomatic CD patients, but further genetic studies with larger number of patients are needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0000000-0219 - Genetsko testiranje bolesnika s kroničnim bolestima tankoga crijeva (Brankica Mijandrušić-Sinčić, )

Ustanove
Medicinski fakultet, Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE