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Pregled bibliografske jedinice broj: 679138

Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling?


Braut, Tamara; Krstulja, Mira; Manestar Rukavina, Koraljka; Jonjić, Nives; Kujundžić, Milodar; Donadić Manestar, Ines; Katunarić, Miljenko; Manestar, Darko
Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling? // Applied immunohistochemistry & molecular morphology, 22 (2014), 9; 674-680 doi:10.1097/PAI.0000000000000014 (međunarodna recenzija, članak, znanstveni)


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Naslov
Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling?

Autori
Braut, Tamara ; Krstulja, Mira ; Manestar Rukavina, Koraljka ; Jonjić, Nives ; Kujundžić, Milodar ; Donadić Manestar, Ines ; Katunarić, Miljenko ; Manestar, Darko

Izvornik
Applied immunohistochemistry & molecular morphology (1062-3345) 22 (2014), 9; 674-680

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cytoplasmic EGFR expression; EGFR gene amplifation; Glottic cancer

Sažetak
Although enhanced EGFR signaling has been connected with glottic cancerogenesis, the precise mechanisms of its activation still remains unclear. The aim of the research was to examine EGFR on protein level confronting cellular pattern of expression and EGFR gene amplification in glottic carcinomas. Tissue microarray technology (TMA) was applied for uniformity of results. Biopsy specimens of patient with glottic squamous cell carcinoma and simple hyperplasia (control samples) were immunostained for EGFR. Immunohistochemical EGFR reaction was analyzed as membrane and cytoplasm positive and compared to the presence of gene amplification obtained by fluorescent in situ hybridization (FISH) analysis obtained previously on a large group of patients. The cytoplasmic distribution of the EGFR (cEGFR) staining appeared as a primary property of some squamous carcinoma cells, different from the membranous reaction, the reactions were mutually exclusive. Significantly higher scores of cEGFR staining were found in carcinomas with gene amplification where the cell reaction was examined in the basal and suprabasal layer. Our results suggest that EGFR expression in squamous cell carcinoma is different regarding tumor cell position in carcinoma with EGFR gene amplification which could be a new indicator of differently driven EGFR-signaling in glottic cancer. Such results with cellular pattern distribution of EGFR protein are worthy of further research.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
062-0620095-0082 - REGULACIJSKI ČIMBENICI ANGIOGENEZE U PROGNOZI TUMORA (Jonjić, Nives, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju

Braut, Tamara; Krstulja, Mira; Manestar Rukavina, Koraljka; Jonjić, Nives; Kujundžić, Milodar; Donadić Manestar, Ines; Katunarić, Miljenko; Manestar, Darko
Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling? // Applied immunohistochemistry & molecular morphology, 22 (2014), 9; 674-680 doi:10.1097/PAI.0000000000000014 (međunarodna recenzija, članak, znanstveni)
Braut, T., Krstulja, M., Manestar Rukavina, K., Jonjić, N., Kujundžić, M., Donadić Manestar, I., Katunarić, M. & Manestar, D. (2014) Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling?. Applied immunohistochemistry & molecular morphology, 22 (9), 674-680 doi:10.1097/PAI.0000000000000014.
@article{article, year = {2014}, pages = {674-680}, DOI = {10.1097/PAI.0000000000000014}, keywords = {Cytoplasmic EGFR expression, EGFR gene amplifation, Glottic cancer}, journal = {Applied immunohistochemistry and molecular morphology}, doi = {10.1097/PAI.0000000000000014}, volume = {22}, number = {9}, issn = {1062-3345}, title = {Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling?}, keyword = {Cytoplasmic EGFR expression, EGFR gene amplifation, Glottic cancer} }
@article{article, year = {2014}, pages = {674-680}, DOI = {10.1097/PAI.0000000000000014}, keywords = {Cytoplasmic EGFR expression, EGFR gene amplifation, Glottic cancer}, journal = {Applied immunohistochemistry and molecular morphology}, doi = {10.1097/PAI.0000000000000014}, volume = {22}, number = {9}, issn = {1062-3345}, title = {Cytoplasmic EGFR staining and gene amplification in glottic cancer - a better indicator of EGFR-driven signaling?}, keyword = {Cytoplasmic EGFR expression, EGFR gene amplifation, Glottic cancer} }

Časopis indeksira:


  • Current Contents Connect (CCC)


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