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Pregled bibliografske jedinice broj: 678897

Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo


Wiens, Matthias; Schroder, Heinz C.; Korzhev, Michael; Wang, Xiao-Hong; Batel, Renato; Muller, Werner E.G.
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo // Marine drugs, 9 (2011), 10; 1969-1994 doi:10.3390/md9101969 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 678897 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo

Autori
Wiens, Matthias ; Schroder, Heinz C. ; Korzhev, Michael ; Wang, Xiao-Hong ; Batel, Renato ; Muller, Werner E.G.

Izvornik
Marine drugs (1660-3397) 9 (2011), 10; 1969-1994

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sponges ; Suberites domuncula ; ASABF ; antimicrobial peptides ; apoptosis ; Bittium sp.

Sažetak
Since sponges, as typical filter-feeders, are exposed to a high load of attacking prokaryotic and eukaryotic organisms, they are armed with a wide arsenal of antimicrobial/cytostatic low-molecular-weight, non-proteinaceous bioactive compounds. Here we present the first sponge agent belonging to the group of ASABF-type antimicrobial peptides. The ASABF gene was identified and cloned from the demospongeSuberites domuncula. The mature peptide, with a length of 64 aa residues has a predicted pI of 9.24, and comprises the characteristic CSαβ structural motif. Consequently, the S. domuncula ASABF shares high similarity with the nematode ASABFs ; it is distantly related to the defensins. The recombinant peptide was found to display besides microbicidal activity, anti-fungal activity. In addition, the peptide lyses human erythrocytes. The expression ofASABF is upregulated after exposure to the apoptosis-inducing agent 2, 2'-dipyridyl. During the process of apoptosis of surface tissue of S. domuncula, grazing gastropods (Bittium sp.) are attracted by quinolinic acid which is synthesized through the kynurenine pathway by the enzyme 3-hydroxyanthranilate 3, 4-dioxygenase (HAD). Finally, the gastropods are repelled from the sponge tissue by the ASABF. It is shown that the effector peptide ASABF is sequentially expressed after the induction of the HAD gene and a caspase, as a central enzyme executing apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Geologija



POVEZANOST RADA


Projekti:
098-0982705-2724 - Učinak zagađenja na programirane biosinteze morskih beskralješnjaka (Batel, Renato, MZOS ) ( POIROT)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Renato Batel (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org fulir.irb.hr

Citiraj ovu publikaciju:

Wiens, Matthias; Schroder, Heinz C.; Korzhev, Michael; Wang, Xiao-Hong; Batel, Renato; Muller, Werner E.G.
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo // Marine drugs, 9 (2011), 10; 1969-1994 doi:10.3390/md9101969 (međunarodna recenzija, članak, znanstveni)
Wiens, M., Schroder, H., Korzhev, M., Wang, X., Batel, R. & Muller, W. (2011) Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo. Marine drugs, 9 (10), 1969-1994 doi:10.3390/md9101969.
@article{article, year = {2011}, pages = {1969-1994}, DOI = {10.3390/md9101969}, keywords = {sponges, Suberites domuncula, ASABF, antimicrobial peptides, apoptosis, Bittium sp.}, journal = {Marine drugs}, doi = {10.3390/md9101969}, volume = {9}, number = {10}, issn = {1660-3397}, title = {Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo}, keyword = {sponges, Suberites domuncula, ASABF, antimicrobial peptides, apoptosis, Bittium sp.} }
@article{article, year = {2011}, pages = {1969-1994}, DOI = {10.3390/md9101969}, keywords = {sponges, Suberites domuncula, ASABF, antimicrobial peptides, apoptosis, Bittium sp.}, journal = {Marine drugs}, doi = {10.3390/md9101969}, volume = {9}, number = {10}, issn = {1660-3397}, title = {Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo}, keyword = {sponges, Suberites domuncula, ASABF, antimicrobial peptides, apoptosis, Bittium sp.} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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