engleski

METALLIC NANOCARRIERS: USEFUL LUMINESCENT BIOMARKERS AND CYTOTOXIC FOES

Certain nanostructures, though, therapeutically and diagnostically promising, have also been shown to induce cytotoxicity both in vitro and in vivo ; cadmium-containing quantum dots (QDs) fall into this category. Compared to traditional fluorophores, QDs have superior photostability and optical properties, including broad spectrum excitation and narrow emission.The objective of this study is to show how some of the critical physicochemical properties, core composition, size, shape and ligands contribute to cytotoxic effects in cells. Our approach in examining toxic effects is to show them by using systematically changed surfaces on the same cores and by investigating the effects in increasingly complex biological systems, from single cells and three dimensional tissue explants to cells in whole animals. Certain nanostructures, though, therapeutically and diagnostically promising, have also been shown to induce cytotoxicity both in vitro and in vivo ; cadmium-containing quantum dots (QDs) fall into this category. Compared to traditional fluorophores, QDs have superior photostability and optical properties, including broad spectrum excitation and narrow emission.The objective of this study is to show how some of the critical physicochemical properties, core composition, size, shape and ligands contribute to cytotoxic effects in cells. Our approach in examining toxic effects is to show them by using systematically changed surfaces on the same cores and by investigating the effects in increasingly complex biological systems, from single cells and three dimensional tissue explants to cells in whole animals.

field-flow fractionation; nanoparticles; nanotoxicity; quantum dots; ROS

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