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Diffuse jejunoileitis - a unique subtype of Crohn's disease? (CROSBI ID 607072)

Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija

Majerović, Matea ; Brinar, Marko ; Crnčević Urek, Marija ; Čuković Čavka, Silvija ; Vucelić, Boris Diffuse jejunoileitis - a unique subtype of Crohn's disease? // Journal of CrohnNULLs and colitis. 2013. str. 273-273

Podaci o odgovornosti

Majerović, Matea ; Brinar, Marko ; Crnčević Urek, Marija ; Čuković Čavka, Silvija ; Vucelić, Boris

engleski

Diffuse jejunoileitis - a unique subtype of Crohn's disease?

Background : Establishment of Crohn's disease (CD) phenotype is helpful in predicting disease behaviour and is crucial in designing our management plan. Within heterogeneous family of disease manifestations considered as CD, diffuse jejunoileitis, although unrecognized as a unique subtype, is associated with high morbidity and represents a true therapeutic challenge. The aim of our study was to assess distinctive features of its behaviour. Methods : Our study evaluated disease location and disease behaviour in 306 patients (pts) with established CD, hospitalized at our Department from January 2004 to October 2012. Data were extracted from their medical records and patients were classified according to the Montreal classification. Regarding disease location they were categorized into three major categories: terminal ileum (L1), colon (L2) and ileocolon (L3). Upper GI location (L4) was added to the latter or, in case of four patients, regarded as a separate category. Patients were further divided in two groups depending on jejunoileal involvement. Perianal disease, if present, was specified. Basic descriptive statistics, including percentiles and medians, were used to interpret results. Results : In a cohort of 306 CD patients we identified 51 pts (16.6%) with upper GI location. Diffuse jejunoileitis was diagnosed in 11 pts (5 (45.5%) male, 6 (54.5%) female) with upper GI involvement and median age at the time of IBD diagnosis was 28 years (range 3-54). Eight of these patients had terminal ileum affected, three had isolated jejunoileal disease. This group had neither concomitant perianal disease nor colonic lesions present. A group of 40 pts without diffuse jejunoileitis included 19 (47.5%) male and 2 (52.2%) female pts, with median age at disease onset of 19, 5 years (range 9-47). They were attributed with disease location as follows: L1+L4 8 pts (20%), L2+L4 2 pts (5%), L3+L4 29 pts (72.5%), and isolated upper GI (L4) 1 pt (2, 5%). Perianal disease (9 pts, 22.5%) was confirmed only in patients with concomitant ileocolitis. Conclusions : Diffuse jejunoileitis is an important, though uncommon, manifestation of Crohn's disease. The results of our study indicate the absence of perianal and colonic involvement in those affected as well as older age at disease onset when compared to patients with upper GI localization without diffuse jejunoileal disease. Even though, according to Montreal classification, it is not recognized as a unique subtype, we have to be aware of the distinct characteristics it exhibits.

diffuse jejunoileitis; Crohn’s disease; subtype disease

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Podaci o prilogu

273-273.

2013.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Journal of CrohnNULLs and colitis

1873-9946

Podaci o skupu

8th Congress of ECCO – the European Crohn's and Colitis Organisation

poster

16.02.2013-18.02.2013

Beč, Austrija

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost