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Pregled bibliografske jedinice broj: 678458

Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.


Katunarić, Miljenko; Zamolo, Gordana
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR. // Medical hypotheses, 79 (2012), 3; 319-320 doi:10.1016/j.mehy.2012.05.021 (međunarodna recenzija, članak, znanstveni)


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Naslov
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.

Autori
Katunarić, Miljenko ; Zamolo, Gordana

Izvornik
Medical hypotheses (0306-9877) 79 (2012), 3; 319-320

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Telomerase ; Dyskerin ; hTR

Sažetak
Telomeres shortening, which leads to apoptosis, is prevented by telomerase adding small repeated segments of DNA to the telomeres. The telomerase level has been correlated with progression of several cancer types, including acute leukemia, breast, prostate, lung cancer and melanoma. Suppression of telomerase activity was found to reduce metastatic potential but could have serious side effects in normal proliferative cells. One of the proteins stabilizing the telomerase complex called dyskerin reduces the maximum telomerase activity. We suggest a possible therapeutic agent which would disable the interaction of dyskerin and telomerase, but would not completely inhibit telomerase activity.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0000000-3545 - Telomerazna aktivnost i imunofenotipske karakteristike limfocita u melanomu kože (Zamolo, Gordana, MZOS ) ( POIROT)
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Gordana Zamolo (autor)

Avatar Url Miljenko Katunarić (autor)

Citiraj ovu publikaciju

Katunarić, Miljenko; Zamolo, Gordana
Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR. // Medical hypotheses, 79 (2012), 3; 319-320 doi:10.1016/j.mehy.2012.05.021 (međunarodna recenzija, članak, znanstveni)
Katunarić, M. & Zamolo, G. (2012) Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.. Medical hypotheses, 79 (3), 319-320 doi:10.1016/j.mehy.2012.05.021.
@article{article, year = {2012}, pages = {319-320}, DOI = {10.1016/j.mehy.2012.05.021}, keywords = {Telomerase, Dyskerin, hTR}, journal = {Medical hypotheses}, doi = {10.1016/j.mehy.2012.05.021}, volume = {79}, number = {3}, issn = {0306-9877}, title = {Modulating telomerase activity in tumor patients by targeting dyskerin binding site for hTR.}, keyword = {Telomerase, Dyskerin, hTR} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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