A dual function of NKG2D ligands in NK-cell activation (CROSBI ID 202230)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Cheney, E.E. ; Wise, E.L. ; Bui, J.D. ; Schreiber, R.D. ; Carayannopoulos, L.N. ; Spitzer, D. ; Zafirova, Biljana ; Polić, Bojan ; Shaw, A.S. ; Markiewicz, M.A.
engleski
A dual function of NKG2D ligands in NK-cell activation
NK-cell killing requires both the expression of activating receptor ligands and low MHC class I expression by target cells. Here we demonstrate that the expression of any of the murine ligands for the NK-cell activating receptor NKG2D results in a concomitant reduction in MHC class I expression. We show this both in tumor cell lines and in vivo. NK-cell lysis is enhanced by the decrease in MHC class I expression, suggesting the change is biologically relevant. These results demonstrate that NKG2D ligand expression on target cells not only allows for activating receptor recognition, but also actively reduces expression of the inhibitory ligand, MHC class I, leading to enhanced recognition and killing by NK cells.
NKG2D; NK cells; NKG2D ligands
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti