Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production (CROSBI ID 202143)
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Podaci o odgovornosti
Grausenburger, Reinhard ; Bilić, Ivan ; Boucheron, Nicole ; Zupkovitz, Gordin ; El-Housseiny, Lamia ; Tschismarov, Roland ; Zhang Yu ; Rembold, Martina ; Gaisberger, Martin ; Hartl, Arnulf ; Epstein, Michelle ; Matthias, Patric ; Seiser, Christian ; Ellmeier, Wilfried
engleski
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production
Chromatin modifications, such as reversible histone acetylation, play a key role in the regulation of T cell development and function. However, the role of individual histone deacetylases (HDACs) in T cells is less well understood. In this article, we show by conditional gene targeting that T cell-specific loss of HDAC1 led to an increased inflammatory response in an in vivo allergic airway inflammation model.
T lymphocytes; development
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Biologija