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IZLOŽENOST ZRAČENJU KROZ DIJAGNOSTIČKE POSTUPKE NUKLEARNE MEDICINE - PRIKAZ SLUČAJA


Kopjar, Nevenka; Prlić, Ivica; Senčar, Jasminka; Želježić, Davor; Ramić, Snježana; Marović, Gordana
IZLOŽENOST ZRAČENJU KROZ DIJAGNOSTIČKE POSTUPKE NUKLEARNE MEDICINE - PRIKAZ SLUČAJA // Zbornik radova 9. Simpozija Hrvatskog društva za zaštitu od zračenja / Knežević, Željka ; Majer, Marija ; Krajcar Bronić, Ines (ur.).
Zagreb: Hrvatsko društvo za zaštitu od zračenja, 2013. str. 235-240 (poster, domaća recenzija, cjeloviti rad (in extenso), znanstveni)


Naslov
IZLOŽENOST ZRAČENJU KROZ DIJAGNOSTIČKE POSTUPKE NUKLEARNE MEDICINE - PRIKAZ SLUČAJA
(RADIATION EXPOSURE BY NUCLEAR MEDICINE IMAGING PROCEDURES: A CASE STUDY)

Autori
Kopjar, Nevenka ; Prlić, Ivica ; Senčar, Jasminka ; Želježić, Davor ; Ramić, Snježana ; Marović, Gordana

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Zbornik radova 9. Simpozija Hrvatskog društva za zaštitu od zračenja / Knežević, Željka ; Majer, Marija ; Krajcar Bronić, Ines - Zagreb : Hrvatsko društvo za zaštitu od zračenja, 2013, 235-240

ISBN
978-953-96133-8-7

Skup
Deveti simpozij Hrvatskog društva za zaštitu od zračenja s međunarodnim sudjelovanjem

Mjesto i datum
Krk, Hrvatska, 10. - 12.04.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Na

Sažetak
Using high-resolution gamma spectrometry, we investigated the activity concentrations of thallium radioisotopes in a urine sample collected during a period of 24 h following nuclear medicine cardiac imaging. As part of a thallium stress test the subject of the study received a radiopharmaceutical preparation with 201Tl (activity 111 MBq). In order to assess whether the cardiac imaging procedure resulted in lymphocyte genome damage, we studied the frequency of sister chromatid exchanges (SCE) and lymphocyte cell kinetics in the blood samples collected before and after the cardiac imaging. The highest activity concentration (538960.9±405.853 Bq/Lurine) was estimated for 201Tl, followed by 1770.539±3.5699 Bq/Lurine for 202Tl, and 422.035±2.091 Bq/Lurine for 200Tl. The applied radiopharmaceutical contained 99.595 % of 201Tl, 0.078 % of 200Tl and 0.327 % of 202Tl. The estimated effective dose received through a single exposure to the radiopharmaceutical and calculated for a period of two days was mostly affected by 201Tl (0.0453 mSv). Due to its half-life of 12.2 days, the contribution of 202Tl (0.0008 mSv) to the effective dose was also significant. Results of the cytogenetic analysis indicate that a single diagnostic exposure to thallium caused an increase of SCE frequency and decrease of the proliferation rate index (PRI). Both parameters normalized steadily 14 days after the cardiac imaging procedure, which is also in accord with data obtained in previous studies. Our results indicate the presence of impurities in the radiopharmaceutical which should contain only 201Tl. This calls for a stricter process of quality control for radiopharmaceuticals used in nuclear medical diagnostic procedures. In this particular case, we emphasize ‘contamination’ with 202Tl, whose contribution to the effective dose cannot be ignored if one takes into account that it has the longest half-life of all three thallium radioisotopes detected in the urine sample.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Fizika, Biologija, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
022-0222882-2335 - RADIOAKTIVNOST OKOLIŠA I ZAŠTITA OD ZRAČENJA (Gordana Marović, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Klinika za tumore