Toward the practical implementation of eye-related bioavailability prediction models (CROSBI ID 202082)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Pepić, Ivan ; Lovrić, Jasmina ; Cetina-Čižmek, Biserka ; Reichl, Stephan ; Filipović-Grčić, Jelena
engleski
Toward the practical implementation of eye-related bioavailability prediction models
The development and registration of reformulated ophthalmic products (OPs) requires eye-related bioavailability (BA) assessments. Common BA algorithms associated with other routes of application, such as the oral route, cannot be easily applied to eye-related BA testing. Here, we provide an analysis of the current literature and suggestions for further directions in the development of high-capacity, cost-effective, and highly predictive nonclinical models of eye-related drug BA. One, or a combination of these models, has the potential for routine use in research laboratories and/or the pharmaceutical industry to overcome various obstacles in reformulated OP development and registration.
Corneal permeability; cell-based models; tissue-based models; eye-related bioavailability
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