engleski

Germline BRCA1/BRCA2 mutations in breast/ovarian cancer families in Croatia : Identification of three novel mutations

Breast cancer is the most commonly diagnosed cancer inwomen after non-melanoma skin cancer, and is the leading cause of cancerrelated deaths in Croatia. Ovarian cancer is in the fifth place, both in incidenceand mortality. About 5−15% of breast cancer and 10% of ovarian cancer casesare hereditary, and germline mutations inBRCA1andBRCA2genes accountfor the majority of hereditary breast and ovarian cancers. The purpose of thisstudy was to estimate the incidence and spectrum of pathogenic mutations inBRCA1/2genes in high risk women in Croatia. This study was funded by TheTerry Fox Run 2009 donation and supported by The Terry Fox Foundation andCroatian League Against Cance

Germline mutations ; BRCA1/BRCA2 ; breast/ovarian cancer

Abstracts of the 22nd Biennial Congress of the European Association for Cancer Research.