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Pregled bibliografske jedinice broj: 675809

The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing


Vukičević, Slobodan; Oppermann, Hermann; Verbanac, Donatella; Jankolija, Morana; Popek, Irena; Curak, Jasna; Brkljačić, Jelena; Pauk, Martina; Erjavec, Igor; Francetić, Igor et al.
The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing // International orthopaedics, 38 (2014), 3; 635-647 doi:10.1007/s00264-013-2201-1 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 675809 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing

Autori
Vukičević, Slobodan ; Oppermann, Hermann ; Verbanac, Donatella ; Jankolija, Morana ; Popek, Irena ; Curak, Jasna ; Brkljačić, Jelena ; Pauk, Martina ; Erjavec, Igor ; Francetić, Igor ; Dumić-Čule, Ivo ; Jelić, Mislav ; Đurđević, Dragan ; Vlahović, Tomislav ; Novak, Ruđer ; Kufner, Vera ; Bordukalo Nikšić, Tatjana ; Kozlović, Marija ; Banić Tomišić, Zrinka ; Bubić-Špoljar, Jadranka ; Bastalić, Ivančica ; Vikić-Topić, Smiljka ; Perić, Mihaela ; Pećina, Marko ; Grgurević, Lovorka

Izvornik
International orthopaedics (0341-2695) 38 (2014), 3; 635-647

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
bone regeneration; bone morphogenetic protein 6; BMP6; bone fracture; OSTEOGROW; whole blood containing device; BMP2; BMP7; commercial bone devices

Sažetak
The purpose of this study was to revise the clinical use of commercial BMP2 (Infuse) and BMP7 (Osigraft) based bone devices and explore the mechanism of action and efficacy of low BMP6 doses in a novel whole blood biocompatible device OSTEOGROW. Complications from the clinical use of BMP2 and BMP7 have been systemically reviewed in light of their role in bone remodeling. BMP6 function has been assessed in Bmp6-/- mice by μCT and skeletal histology, and has also been examined in mesenchymal stem cells (MSC), hematopoietic stem cells (HSC) and osteoclasts. Safety and efficacy of OSTEOGROW have been assessed in rats and rabbits. Clinical use issues of BMP2 and BMP7 have been ascribed to the limited understanding of their role in bone remodeling at the time of device development for clinical trials. BMP2 and BMP7 in bone devices significantly promote bone resorption leading to osteolysis at the endosteal surfaces, while in parallel stimulating exuberant bone formation in surrounding tissues. Unbound BMP2 and BMP7 in bone devices precipitate on the bovine collagen and cause inflammation and swelling. OSTEOGROW required small amounts of BMP6, applied in a biocompatible blood coagulum carrier, for stimulating differentiation of MSCs and accelerated healing of critical size bone defects in animals, without bone resorption and inflammation. BMP6 decreased the number of osteoclasts derived from HSC, while BMP2 and BMP7 increased their number. Current issues and challenges with commercial bone devices may be resolved by using novel BMP6 biocompatible device OSTEOGROW, which will be clinically tested in metaphyseal bone fractures, compartments where BMP2 and BMP7 have not been effective.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-3652 - Genska terapija mineraliziranih tkiva (Pećina, Marko, MZOS ) ( POIROT)
108-1080114-0017 - Genotipovi i činitelji virulencije uzročnika bolničkih infekcija (Budimir, Ana, MZOS ) ( POIROT)
108-1080327-0320 - Uloga TSH u modelu osteoporoze i u bolesnica sa smanjenom koštanom masom (Vukičević, Slobodan, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi link.springer.com

Citiraj ovu publikaciju:

Vukičević, Slobodan; Oppermann, Hermann; Verbanac, Donatella; Jankolija, Morana; Popek, Irena; Curak, Jasna; Brkljačić, Jelena; Pauk, Martina; Erjavec, Igor; Francetić, Igor et al.
The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing // International orthopaedics, 38 (2014), 3; 635-647 doi:10.1007/s00264-013-2201-1 (međunarodna recenzija, pregledni rad, znanstveni)
Vukičević, S., Oppermann, H., Verbanac, D., Jankolija, M., Popek, I., Curak, J., Brkljačić, J., Pauk, M., Erjavec, I. & Francetić, I. (2014) The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing. International orthopaedics, 38 (3), 635-647 doi:10.1007/s00264-013-2201-1.
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Oppermann, Hermann and Verbanac, Donatella and Jankolija, Morana and Popek, Irena and Curak, Jasna and Brklja\v{c}i\'{c}, Jelena and Pauk, Martina and Erjavec, Igor and Franceti\'{c}, Igor and Dumi\'{c}-\v{C}ule, Ivo and Jeli\'{c}, Mislav and \DJur\djevi\'{c}, Dragan and Vlahovi\'{c}, Tomislav and Novak, Ru\djer and Kufner, Vera and Bordukalo Nik\v{s}i\'{c}, Tatjana and Kozlovi\'{c}, Marija and Bani\'{c} Tomi\v{s}i\'{c}, Zrinka and Bubi\'{c}-\v{S}poljar, Jadranka and Bastali\'{c}, Ivan\v{c}ica and Viki\'{c}-Topi\'{c}, Smiljka and Peri\'{c}, Mihaela and Pe\'{c}ina, Marko and Grgurevi\'{c}, Lovorka}, year = {2014}, pages = {635-647}, DOI = {10.1007/s00264-013-2201-1}, keywords = {bone regeneration, bone morphogenetic protein 6, BMP6, bone fracture, OSTEOGROW, whole blood containing device, BMP2, BMP7, commercial bone devices}, journal = {International orthopaedics}, doi = {10.1007/s00264-013-2201-1}, volume = {38}, number = {3}, issn = {0341-2695}, title = {The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing}, keyword = {bone regeneration, bone morphogenetic protein 6, BMP6, bone fracture, OSTEOGROW, whole blood containing device, BMP2, BMP7, commercial bone devices} }
@article{article, author = {Vuki\v{c}evi\'{c}, Slobodan and Oppermann, Hermann and Verbanac, Donatella and Jankolija, Morana and Popek, Irena and Curak, Jasna and Brklja\v{c}i\'{c}, Jelena and Pauk, Martina and Erjavec, Igor and Franceti\'{c}, Igor and Dumi\'{c}-\v{C}ule, Ivo and Jeli\'{c}, Mislav and \DJur\djevi\'{c}, Dragan and Vlahovi\'{c}, Tomislav and Novak, Ru\djer and Kufner, Vera and Bordukalo Nik\v{s}i\'{c}, Tatjana and Kozlovi\'{c}, Marija and Bani\'{c} Tomi\v{s}i\'{c}, Zrinka and Bubi\'{c}-\v{S}poljar, Jadranka and Bastali\'{c}, Ivan\v{c}ica and Viki\'{c}-Topi\'{c}, Smiljka and Peri\'{c}, Mihaela and Pe\'{c}ina, Marko and Grgurevi\'{c}, Lovorka}, year = {2014}, pages = {635-647}, DOI = {10.1007/s00264-013-2201-1}, keywords = {bone regeneration, bone morphogenetic protein 6, BMP6, bone fracture, OSTEOGROW, whole blood containing device, BMP2, BMP7, commercial bone devices}, journal = {International orthopaedics}, doi = {10.1007/s00264-013-2201-1}, volume = {38}, number = {3}, issn = {0341-2695}, title = {The clinical use of bone morphogenetic proteins (BMPs) revisited: A novel BMP6 biocompatible carrier device OSTEOGROW for bone healing}, keyword = {bone regeneration, bone morphogenetic protein 6, BMP6, bone fracture, OSTEOGROW, whole blood containing device, BMP2, BMP7, commercial bone devices} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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