engleski

Therapy of Helicobacter pylori infection

Abstract. The clinical significance of H. pylori infection in the etiopathogenesis of many gastric and duodenal diseases, peptic ulcer in particular, as well as the current awareness of the benefits of its eradication has produced crucial changes in the treatment of these diseases. Eradication was already defined as the disappearance of H. pylori from the gastric mucosa (finding negativization) confirmed at least 4 weeks (or later) after completed antibiotic eradication therapy. The regimen has to be simple, cheap and tolerable so that the patient could carry it out completely and as easy as possible (good compliance is required). The success of H. pylori eradication, evaluated by the strict "intention-to-treat" criteria, has to be higher than 80%. Current modern therapy should be triple and not longer than 7 days. One of three proton pump inhibitors is recommended as the antisecretory component (omeprazole, pantoprazole or lansoprazole). Two of three following antibiotic is added to this therapy: metronidazole/tinidazole, clarithromycin or amoxicillin.

Helicobacter pylori; therapy; eradication

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