engleski

Supportive transfusion therapy of acute leukemia patients and patients submitted to autologous bone marrow transplantation (ABMT)

Transfusion of blood and blood components is usually a safe and effective way to correct hematologic deficits. However, Transfusion is not devoid of risks and adverse effects. For this reason, supportive Transfusion therapy must be properly indicated and strictly controlled. The aim of our retrospective study was to measure the consumption of blood components in acute leukemia patients treated with induction chemotherapy and in patients who underwent ABMT, to compare the consumption of blood components between these two groups of patients and to estimate the influence of sex, age and type of therapy on the blood components consumption. Seventy-four patients treated at our department from September 1993 to june 1996 were included in the study. There were 48 acute leukemia patients treated with induction chemotherapy (median age 48, range 19-74 years) and 26 patients treated with ABMT (median age 26, range 18-48 years). Collected data were statistically evaluated, and differences were examined for the statistical significance using the Kruskal-Wallis one-way analysis by ranks and one-way analysis of variance. The average monthly consumption per acute leukemia patient treated with induction chemotherapy was 1689.6 ml of red blood cell (RBC) concentrates and 32.07 units of platelet concentrates, while in patients who underwent ABMT the average monthly consumption was statistically significantly lower (596.4 ml of RBC concentrates and 20.7 units of platelet concentrates per patient). The highest consumption of blood components was noticed in AML patients (on average - 1847.7 ml of RBC concentrates and 34.8 units of platelet concentrates a month), while in ALL patients this consumption was significantly lower (on average - 997.5 ml of RBC concentrates and 18.6 units of platelet concentrates a month). Comparing the influence of patients' sex on blood components consumption, we proved that this consumption was higher in female patients. The analysis of blood components consurnption as regards patients' age showed a higher consumption in patients over 35 years, but without any statistical significance. These results can be useful in planning of Transfusion support.

acute leukemia; ABMT; RBC concentrates; platelet concentrates

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