engleski

METABOLIC SYNDROME: EFFECTS OF PPARγ, APOE, LPL, IL-6, ACE AND AT1R GENE VARIANTS

Background. The role of genetic factors in the development of metabolic syndrome (MS) has been widely recognized, but the contribution of genes has not yet been fully clarified. We investigated the possible role of gene polymorphisms of PPARγ (Pro12Ala), ApoE (ε2, ε3, ε4), LPL (P+/-), IL-6 (-174G>C), ACE (I/D) and AT1R (1166A>C) in MS. Methods. Genotyping of PPARγ, LPL, IL-6, AT1R and ACE was performed by PCR-RFLP, and of APOE by real-time PCR in a group of 263 patients and 180 controls. Results. We found association of LPL variants with waist circumference (p=0.02), BMI, LDL and HDL (p=0.05) ; APOE and ACE significantly corelated to cholesterol (p=0.01), D and E2 allele contributed to its increased level while APOE2 corelated to lower HDL (p=0.03) ; ACE and AT1R variants correlated with LDL cholesterol (p=0.04) ; ACE D predisposed to increased glucose level (p=0.02). Borderline associations were found between blood pressure and combination of variant alleles of PPARg and APOE (p=0.06), APOE and ACE (p=0.06) ; BMI and APOE (p=0.06). Conclusion. Gene variants of APOE, LPL, ACE, AT1R and PPARγ could be susceptibility factors of obesity, lipid status, and glucose intolerance contributing to development of MS.

metabolic syndrome; gene variants; PPARγ; APOE; LPL; IL-6; ACE; AT1R

nije evidentirano