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Pregled bibliografske jedinice broj: 674462

Use of phosphate-binding agents is associated with a lower risk of mortality


Cannata-Andía, J.B.; ...; Ćović, Adrian; ...; Pavlović, Draško; ...; Zoccali, C.
Use of phosphate-binding agents is associated with a lower risk of mortality // Kidney international, 84 (2013), 998-1008 doi:10.1038/ki.2013.185 (međunarodna recenzija, članak, znanstveni)


Naslov
Use of phosphate-binding agents is associated with a lower risk of mortality

Autori
Cannata-Andía, J.B. ; ... ; Ćović, Adrian ; ... ; Pavlović, Draško ; ... ; Zoccali, C.

Izvornik
Kidney international (0085-2538) 84 (2013); 998-1008

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dialysis; hyperparathyroidism; hyperphosphatemia; mineral metabolism; mortality risk; phosphate binders

Sažetak
Hyperphosphatemia has been associated with higher mortality risk in CKD 5 patients receiving dialysis. Here, we determined the association between the use of single and combined phosphate- binding agents and survival in 6797 patients of the COSMOS study: a 3-year follow-up, multicenter, open-cohort, observational prospective study carried out in 227 dialysis centers from 20 European countries. Patient phosphate-binding agent prescriptions (time-varying) and the case- mix–adjusted facility percentage of phosphate- binding agent prescriptions (instrumental variable) were used as predictors of the relative all-cause and cardiovascular mortality using Cox proportional hazard regression models. Three different multivariate models that included up to 24 variables were used for adjustments. After multivariate analysis, patients prescribed phosphate-binding agents showed a 29 and 22% lower all-cause and cardiovascular mortality risk, respectively. The survival advantage of phosphate- binding agent prescription remained statistically significant after propensity score matching analysis. A decrease of 8% in the relative risk of mortality was found for every 10% increase in the case-mix–adjusted facility prescription of phosphate-binding agents. All single and combined therapies with phosphate-binding agents, except aluminum salts, showed a beneficial association with survival. The findings made in the present association study need to be confirmed by randomized controlled trials to prove the observed beneficial effect of phosphate-binding agents on mortality.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
219-2192376-2092 - Biomehanika čvrstih organskih tkiva (Vasilije Nikolić, )

Ustanove
KBC "Sestre Milosrdnice",
Medicinski fakultet, Osijek

Autor s matičnim brojem:
Draško Pavlović, (43983)

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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