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Continuous Compared With Cyclic Oral Contraceptives for the Treatment of Primary Dysmenorrhea : A Randomized Controlled Trial (CROSBI ID 201508)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Dmitrović, Romana ; Kunselman, Allen R. ; Legro, Richard S. Continuous Compared With Cyclic Oral Contraceptives for the Treatment of Primary Dysmenorrhea : A Randomized Controlled Trial // Obstetrics and gynecology, 119 (2012), 6; 1143-1150. doi: 10.1097/AOG.0b013e318257217a

Podaci o odgovornosti

Dmitrović, Romana ; Kunselman, Allen R. ; Legro, Richard S.

engleski

Continuous Compared With Cyclic Oral Contraceptives for the Treatment of Primary Dysmenorrhea : A Randomized Controlled Trial

OBJECTIVE: To estimate whether continuous oral contraceptive pills (OCPs) will result in more pain relief in primary dysmenorrhea patients than cyclic OCPs, which induce withdrawal bleeding with associated pain and symptoms. METHODS: We conducted a double-blind, randomized, controlled trial comparing continuous to a cyclic 21-7 OCP regimen (gestodene 0.075 mg and ethinyl estradiol 20 microgram) for 6 months in 38 primary dysmenorrhea patients. The primary outcome was the difference in subjective perception of pain as measured by the visual analog scale over a period of 6 months. RESULTS: Twenty-nine patients completed the study. In both groups, pain reduction measured by visual analog scale declined over time and was significant at 6 months compared with baseline, with no difference between groups. Continuous regimen was superior to cyclic regimen after 1 month (mean difference -27.3, 95% confidence interval [CI] -40.5 to -14.2 ; P<.001) and 3 months (mean difference -17.8, 95% CI -33.4 to -2.1 ; P=.03) of treatment. Secondary outcomes noted no difference between groups in terms of menstrual distress as measured by the Moos Menstrual Distress Questionnaire. After 6 months, there was an increase in weight and a decrease in systolic blood pressure in the continuous group compared with the cyclic group. CONCLUSION: Both regimens of OCPs are effective in the treatment of primary dysmenorrhea. Continuous OCPs outperform cyclic OCPs in the short term, but this difference is lost after 6 months. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00517556. LEVEL OF EVIDENCE: I.

primary dysmenorrhea; oral contraceptives

Rad je kao predavanje prezentiran na 67th Annual Meeting of the American Society for Reproductive Medicine, održanom od 15.-18.10.2011.g., Orlando, Florida, SAD.

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Podaci o izdanju

119 (6)

2012.

1143-1150

objavljeno

0029-7844

1873-233X

10.1097/AOG.0b013e318257217a

Povezanost rada

Kliničke medicinske znanosti

Poveznice
Indeksiranost