engleski

Biomarkers of inflammation in canine lymphoma

Background. Cancer is a major cause of morbidity and mortality within the canine population and the most common canine haematopoietic neoplasm is lymphoma. Canine lymphoma represents a model for human non-Hodgkin lymphoma due to histological similarities in many respects. Recent data have expanded the concept that inflammation is a critical component of tumour initiation and progression. Cellular adhesion molecules have also been implicated in tumour progression and metastasis. Objective. The aim of this study was to evaluate inflammatory biomarker levels in canine lymphoma. Methods. A total of 15 dogs presenting with cytologically confirmed diagnosis of lymphoma and 15 healthy dogs were included in this study. ELISA assay of serum high sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6), high mobility group box-1 proteins (HMGB-1), soluble intercellular adhesive molecule-1 (sICAM-1), plasminogen activator inhibitor- 1 (PAI-1) and soluble urokinase receptor of plasminogen activator (suPAR) was determined using a canine kits obtained from Biotang (Biotang Source International, Camarillo, USA), following the manufacturer instructions. Results. Dogs with lymphoma had significantly higher levels of hsCRP, ICAM-1 and IL-6 comparing to healthy dogs. Results suggested proinflammatory status of dogs with lymphoma. Inflammation is known to be involved in the initiation and progression of cancer. The chronic, low-grade inflammation associated with cancer is reflected by elevated levels of hsCRP as a result of chronic stimulation with proinflammatory cytokine IL-6. The adhesion molecules are intimately involved in inflammatory reactions, but more recently a role in tumour progression has been postulated. Increased ICAM-1 expression may play a role in tumour cell adhesion to the vascular endothelium, which precedes extravasation of cells and the development of metastases. Further studies are warranted to determine whether measurement of these inflammatory biomarkers are beneficial in the diagnosis and monitoring of canine lymphoma.

HMBG-1 ; sICAM-1 ; IL-6 ; fibrinolysis

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