Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia (CROSBI ID 79074)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Gagro, Alenka ; Dašić, Gorana ; Sabioncello, Ante ; Rabatić, Sabina ; Reckzeh, Barbara ; Havemann, Klaus ; Kardum, Ika ; Jakšić, Branimir ; Vitale, Branko Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia // Leukemia & lymphoma, 25 (1997), 3-4; 301-311-x

Podaci o odgovornosti

Gagro, Alenka ; Dašić, Gorana ; Sabioncello, Ante ; Rabatić, Sabina ; Reckzeh, Barbara ; Havemann, Klaus ; Kardum, Ika ; Jakšić, Branimir ; Vitale, Branko

engleski

Phenotypic analysis of receptor-ligand pairs on B-cells in B-chronic lymphocytic leukemia

Whole-blood three-color immunofluorescence analysis was used to investigate the role of CD5/CD72 and CD21/CD23 receptor-ligand pair formation on B-chronic lymphocytic leukemia (B-CLL) cells as well as sCD23 and bcl-2 oncoprotein expression in disease progression and activity and total tumor mass in B-cell chronic leukemia (B-CLL) patients. Thirty-four patients with B-CLL and 19 controls were included in the study. The majority of B-cells in B-CLL patients coexpressed CD5 and CD72 as well as the CD23 antigen. Unlike B-cells in B-CLL patients, B-cells in all healthy controls tested had high expression of CD21 antigen. We identified two groups of B-CLL patients according to high (n = 20) or low levels (n = 14) of CD21 expression on CD19+CD23+ B-cells. Only in the patients with high CD21 expression, were sCD23 levels positively correlated with factors known to have prognostic significance in B-CLL (Rai stage and TTM) and could, therefore, be used as a prognostic parameter for these B-CLL patients. Bcl-2 oncoprotein expression did not differ between these patient groups. We presumed that in patients with a lower expression of CD21 antigen, the contribution of the CD21 molecule to homotypic adhesion was lacking. Further studies are necessary to determine the possible association of higher expression of the CD21 antigen with disease progression and the aggressive character of the B-CLL.

chronic lymphocytic leukemia; immunophenotype; receptor ligand pairs

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

25 (3-4)

1997.

301-311-x

objavljeno

1042-8194

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Indeksiranost