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Deleterious Effect of Mycotoxin Combinations Involving Ochratoxin A


Šegvić Klarić, Maja; Rašić, Dubravka; Peraica, Maja
Deleterious Effect of Mycotoxin Combinations Involving Ochratoxin A // Toxins, 5 (2013), 1965-1987 doi:10.3390/toxins5111965 (međunarodna recenzija, pregledni rad, znanstveni)


Naslov
Deleterious Effect of Mycotoxin Combinations Involving Ochratoxin A

Autori
Šegvić Klarić, Maja ; Rašić, Dubravka ; Peraica, Maja

Izvornik
Toxins (2072-6651) 5 (2013); 1965-1987

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Mycotoxin interactions; chronic renal diseases; genotoxicity; carcinogenicity

Sažetak
Ochratoxin A (OTA) is a nephrotoxic mycotoxin with carcinogenic properties. Its presence was detected in various foodstuffs all over the world but with significantly higher frequency and concentrations in areas with endemic nephropathy (EN). Even though food is often contaminated with more than one mycotoxin, earlier studies focused on the occurrence and toxicology of only OTA. Only a limited number of surveys showed that OTA co- occurs in food with mycotoxins (citrinin-CIT, penicilic acid, fumonisin B1-FB1, aflatoxins-AF) which exert nephrotoxic, carcinogenic or carcinogen-promoting activity. This review summarises the findings on OTA and its co- occurrence with the mentioned mycotoxins in food as well as experimental data on their combined toxicity. Most of the tested mycotoxin mixtures involving OTA produced additive or synergistic effects in experimental models suggesting that these combinations represent a significant health hazard. Special attention should be given to mixtures that include carcinogenic and cancer- promoting mycotoxins.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
006-0061117-1242 - Mikromicete, interakcije toksičnih metabolita-zdravlje i prevencija (Maja Šegvić Klarić, )
022-0222148-2142 - Toksični učinci mikotoksina na ljude i životinje (Maja Peraica, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut za medicinska istraživanja i medicinu rada, Zagreb

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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