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Pregled bibliografske jedinice broj: 673730

AICAR induces differentiation of acute myeloid leukemia cells


Lalić, Hrvoje; Dembitz, Vilma; Lukinović-Škudar, Vesna; Banfić, Hrvoje; Višnjić, Dora
AICAR induces differentiation of acute myeloid leukemia cells // Leukemia & lymphoma, 55 (2014), 10; 2375-2383 doi:10.3109/10428194.2013.876633 (međunarodna recenzija, članak, znanstveni)


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Naslov
AICAR induces differentiation of acute myeloid leukemia cells

Autori
Lalić, Hrvoje ; Dembitz, Vilma ; Lukinović-Škudar, Vesna ; Banfić, Hrvoje ; Višnjić, Dora

Izvornik
Leukemia & lymphoma (1042-8194) 55 (2014), 10; 2375-2383

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
AICAR; differentiation markers; leukemia

Sažetak
AMP-activated kinase (AMPK) modulators have been shown to exert cytotoxic activity in hematological malignancies, but their role in differentiation of acute myeloid leukemia (AML) is less explored. In this study, the effects of AMPK agonists on all- trans retinoic acid (ATRA)-mediated differentiation of acute promyelocytic leukemia (APL) and non-APL AML cell lines were investigated. The results show that APMK agonists inhibit growth of myeloblastic HL-60, promyelocytic NB4 and monocytic U937 cells. 5- aminoimidazole-4-carboxamide ribonucleoside (AICAR), an AMPK activator, enhances ATRA-mediated differentiation of NB4 cells. In U937 cells, AICAR alone induces the expression of cell surface markers associated with mature monocytes and macrophages. In both cell lines, AICAR increases the activity of mitogen-activated protein kinase (MAPK), and the presence of a MAPK inhibitor reduces the expression of differentiation markers. These results revealed beneficial effects of AICAR in AML, including differentiation of non-APL AML cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
108-1081347-1448 - Uloga PLC i Akt u staničnom ciklusu i diferencijaciji leukemija (Dora Višnjić, )
108-1081347-0173 - Funkcija fosfoinozitol 3-kinaze C2 beta u staničnim jezgrama (Hrvoje Banfić, )

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Lalić, Hrvoje; Dembitz, Vilma; Lukinović-Škudar, Vesna; Banfić, Hrvoje; Višnjić, Dora
AICAR induces differentiation of acute myeloid leukemia cells // Leukemia & lymphoma, 55 (2014), 10; 2375-2383 doi:10.3109/10428194.2013.876633 (međunarodna recenzija, članak, znanstveni)
Lalić, H., Dembitz, V., Lukinović-Škudar, V., Banfić, H. & Višnjić, D. (2014) AICAR induces differentiation of acute myeloid leukemia cells. Leukemia & lymphoma, 55 (10), 2375-2383 doi:10.3109/10428194.2013.876633.
@article{article, year = {2014}, pages = {2375-2383}, DOI = {10.3109/10428194.2013.876633}, keywords = {AICAR, differentiation markers, leukemia}, journal = {Leukemia and lymphoma}, doi = {10.3109/10428194.2013.876633}, volume = {55}, number = {10}, issn = {1042-8194}, title = {AICAR induces differentiation of acute myeloid leukemia cells}, keyword = {AICAR, differentiation markers, leukemia} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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