engleski

GENDER-SPECIFIC EFFECTS OF PPARG, APOE, ACE, LPL, IL-6 AND AT1R GENE VARIANTS ON METABOLIC SYNDROME

Background. Metabolic syndrome (MS) is a cluster of modifiable risk factors including hypertension, abdominal obesity, dyslipidemia and insulin resistance, associated with nonmodifiable risk factors, such as age, sex and genetic background. We investigated the possible role of gene polymorphisms of PPARG (Pro12Ala), ApoE (ε2, ε3, ε4), LPL (P+/-), IL-6 (-174G>C), ACE (I/D) and AT1R (1166A>C) in MS. Methods. 516 individuals were investigated including 263 patients with MS and 253 subjects without MS criteria. Genotyping was performed using PCR based methods. Results. In female group associations were found for: LPL and ACE with MS (p=0.04) ; PPARG and LPL with blood pressure, (p=0.04) ; LPL with cholesterol and LDL (p=0.01 and p=0.05, respectively). Significant gene interactions observed between: APOE and PPARG, ACE and APOE were associated with BMI (p=0.01 and p=0.05, respectively) ; LPL and PPARG were associated with triglycerides (p=0.03). For males we found associations of: LPL variants with MS (p=0.02), BMI (p=0.002) and waist circumference (p=0.008) ; PPARG and APOE with BMI (p=0.05) ; IL-6 with CRP (p=0.02). Significant gene interactions observed between: PPARG and AT1R were associated with blood pressure (p=0.05) ; PPARG and APOE with triglycerides (p=0.02) ; PPARG and APOE, PPARG and IL6 (p=0.03), ACE and APOE (p=0.0002) with cholesterol ; PPARG and LPL (p=0.003), PPARG and IL6 (p=0.06) with HDL ; PPARG and IL6 (p=0.01), ACE and APOE (p=0.04) ; PPARG and APOE, LPL and ACE (p=0.01), AT1R and ACE (p=0.06) with CRP. Conclusion. Gene variants of PPARG, APOE, LPL, ACE, AT1R and IL-6 could be susceptibility factors of obesity, lipid status, and glucose intolerance.

metabolic syndrome; gene variants

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