Lupus vulgaris following BCG vaccination (CROSBI ID 606219)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Gagro, Alenka ; Pustišek, Nives ; Kapović, Agneza Marija ; Katalinić-Janković, Vera
engleski
Lupus vulgaris following BCG vaccination
Lupus vulgaris is a rare form of cutaneous mycobacterial infection in children. Most cases follow hematogenous or lymphatic seeding, and more rarely from exposure to bacillus Calmette-Guérin (BCG) vaccine. We report a 6-month old girl presented with a 3-month history of an erythematous plaques with central atrophy and a scaly border on her left arm and on both cheeks. The first lesion developed in the vicinity of the vaccination site with BCG two months after vaccination (intradermal injection ; 0.05 mL). Her family history was negative for immune diseases and parents denied consanguinity. She presented with no failure to thrive and had no signs of regional lymphadenopathy. All routine laboratory as well as her serum immunoglobulins, peripheral blood immunophenotypic analysis, T cell proliferation assay (PHA, PWM and ConA), and phagocytosis were normal. There were no signs of possible BCG dissemination. Interferon-Gamma Release Assay test (QuantiFERON®-TB Gold In-Tube test) was negative and PPD positive. A biopsy of skin lesion from her arm revealed granulomas formed mainly of histiocytes, lymphocytes, and multinucleated giant cells. The diagnosis of lupus vulgaris induced BCG vaccination was confirmed by polymerase chain reaction for mycobacterial complex after histology while culture was negative for mycobacteria. The treatment with rifampicin and isoniazid was introduced with excellent clinical response and no side effects. About 60 cases of BCG-induced lupus vulgaris have been reported in the literature and the estimated incidence is only 5 per million vaccinations. The factors responsible for the development of BCG-induced lupus vulgaris are unknown but may include inherent susceptibility of the host. Patient’s DNA is sent abroad for whole exome sequencing to search for causative mutations that might predisposed her to this type of rare complication of BCG vaccine.
BCG; IFN-gamma; vaccine
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Podaci o prilogu
2013.
objavljeno
Podaci o matičnoj publikaciji
Abstract Book
Podaci o skupu
2nd Joint Meeting of Middle-European Societies for Immunology and Allergology
poster
10.10.2013-13.10.2013
Opatija, Hrvatska