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Pregled bibliografske jedinice broj: 673054

Ductal plate malformation in patients with biliary atresia


Vuković, Jurica; Grizelj, Ruža; Bojanić, Katarina; Ćorić, Marijana; Luetić, Tomislav; Batinica, Stipe; Kujundžić Tiljak, Mirjana; Schroeder Darrell, R; Sprung, Juraj
Ductal plate malformation in patients with biliary atresia // European journal of pediatrics, 141 (2012), 12; 1799-1804 doi:10.1007/s00431-012-1820-7 (međunarodna recenzija, članak, znanstveni)


Naslov
Ductal plate malformation in patients with biliary atresia

Autori
Vuković, Jurica ; Grizelj, Ruža ; Bojanić, Katarina ; Ćorić, Marijana ; Luetić, Tomislav ; Batinica, Stipe ; Kujundžić Tiljak, Mirjana ; Schroeder Darrell, R ; Sprung, Juraj

Izvornik
European journal of pediatrics (0340-6199) 141 (2012), 12; 1799-1804

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Ductal plate malformation; biliary atresia; liver histopatology

Sažetak
The presence of ductal plate malformation (DPM+) on liver histology in children with biliary atresia (BA) is a marker of early intrauterine disease onset and an indication of an unfavorable prognosis. We studied the prognostic value of DPM in infants with BA after hepatoportoenterostomy (HPE). We reviewed 28 BA patients who underwent HPE in a single medical center. We examined the time of jaundice onset after delivery (conjugated hyperbilirubinemia): early onset (fetal phenotype with no jaundice-free interval) vs. late onset (perinatal phenotype with jaundice-free interval) and the presence or absence of DPM (DPM+ or DPM-) histopathology. Primary outcome was jaundice clearance at 3 months after HPE and survival with native liver (SNL). Eight children had fetal and 20 had perinatal BA (8 DPM+, 12 DPM-). At 3 months after HPE, no patients with fetal BA had achieved jaundice clearance, while jaundice clearance was achieved in five patients with DPM+ perinatal disease and four patients with DPM- perinatal BA (P = 0.03, comparing all three groups ; P = 0.36, comparing DPM+ vs. DPM- perinatal patients). Median SNL was 8.6 months for fetal BA patients, 148.2 months for DPM+ perinatal BA patients, and 93.2 months for DPM- perinatal BA patients (log-rank test, P < 0.001, comparing all three groups ; P = 0.59, comparing DPM+ vs. DPM- perinatal patients). After adjusting for BA type, age older than 2 months at HPE was associated with worse SNL [P = 0.03 ; hazard ratio = 4.0 (95 % CI, 1.1-14.2)]. Conclusions: Early onset of jaundice, regardless of DPM histology, was the most ominous sign of poor outcome in infants with BA after HPE.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-0532264-0048 - Hepatocelularni tumori (Marijana Ćorić, )
108-1080316-0299 - Kako mjeriti zdravlje? (Mirjana Kujundžić Tiljak, )

Ustanove
Hrvatski zavod za javno zdravstvo,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • MEDLINE


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