engleski

Metabolic disturbances between overweight and lean prehypertensives

AIM: To test differences in metabolic characteristics among overweight and normally weighted prehypertensives. DESIGN AND METHODS: Out of 2489 subjects enrolled in Croatian rural study, 117 prehypertensives(53 women, 64 men) were included in this analysis. All subjects had blood pressure (BP)and heart rate(HR) measured following the ESH guidelines. BMI and waist circumference(WC) were determined. Fasting blood was analysed for glucose(FBG), insulin, total cholesterol(T-C), HDL, LDL, triglycerides(TG), serum creatinine, haematocrite(Hct), C reactive protein(CRP) and white blood cell count(WBC). HOMA index was used to calculate insulin resistance and MDRD formula to estimate glomerular filtration rate (eGFR). Albumin to creatinine ratio(ACR) and alpha1 microglobin to creatinine ratio(alpha1CR) were determined. Subjects were divided in two groups: group 1: (BMI<25 and WC<92cm, N=53) and group 2 (BMI>=25 and WC>=92, N=64). RESULTS: The two groups didn't differ significantly neither in age, in BP nor in HR values (p>0.05). Furthermore, no difference was found in inflammatory markers such as CRP and WBC (p>0.05), but interestingly we found significant difference in hematocrite (0.38 vs 0.40, p=0.0036). Two groups didn't differ in renal function parameters (p>0.05). Finally, we found group 2 to be significantly dislipidemic than group 1, to have higher FBG, insulin and HOMA values (Table 1). CONCLUSION: Significant differences in majority of the cardiovascular risk factors were observed between the overweight and normaly weighted prehypertensives. Drug treatment of prehypertension is still being debated. Higher cardiovascular risk factors in overweight, (but yet not obese) prehypertensive subjects may point out on the target group for potential drug treatment.

prehypertension ; metabolic disturbances ; weight

nije evidentirano