engleski

Prehypertension is characterized with higher risk profile but not with lower adiponectin values

Objective: As the role of adiponectin on blood pressure (BP) is still not elucidated, our aim was to determine relationship between adiponectin values and BP in general rural population. Design and method: Out of 2489 subjects enrolled in Croatian rural study, 693 were eligible for further analysis. Exclusion criteria were antihypertensive treatment, hypertension stage 2, 3 and isolated systolic hypertension, diabetes mellitus, pregnancy, chronic terminal diseases, dementia, immobility and missing data. BP was measured following the ESH guidelines. Anthropometric measurements (height, weight, and BMI and waist circumference) were determined. Fasting blood was analysed for glucose, insulin, total cholesterol, HDL, LDL, triglycerides. HOMA index was used to calculate insulin resistance. Subjects were divided in three groups: optimal BP (<=120/80 ; N=316), prehypertensives (130/85- 139/89 ; N=210), and untreated hypertensives stage 1(140-159/90-99 ; N=167). Results: The three groups didn’t differ significantly in adiponectine values (p=0.2641). Significant differences in other variables beside HDL cholesterol were observed between groups as shown in table. Adiponectin correlate significantly with BMI, HDL, weight and waist circumference ( rho=-0.34, 0.39, -0.36, -0.30 respectively ; p<0.05), but not with BP, triglycerides, LDL, insulin, HOMA index (p>0.05). Conclusions: Prehypertensives have higher values of known cardiovascular risk factors than optimal BP subjects have. Our results do not confirm association of adiponectin with BP in general rural population. Further studies with larger number of subjects are needed.

adiponectin ; cardiovascular risk ; hypertension ; prehypertension

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