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Pregled bibliografske jedinice broj: 672947

Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia


Konja, Josip; Rajić, Ljubica; Čulić, Srđana; Roganović, Jelena; Bilić, Ernest; Femenić, Ranka: Lasan Trčić, Ružica; Batinić, Drago; Jakovljević, Gordana; Aničić, Mirna
Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia // ESMO Congress 2012 : abstracts, 2013. str. 359-359 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 672947 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia

Autori
Konja, Josip ; Rajić, Ljubica ; Čulić, Srđana ; Roganović, Jelena ; Bilić, Ernest ; Femenić, Ranka: Lasan Trčić, Ružica ; Batinić, Drago ; Jakovljević, Gordana ; Aničić, Mirna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
ESMO Congress 2012 : abstracts / - , 2013, 359-359

Skup
ESMO Congress

Mjesto i datum
, 2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
acute lymphoblastic leukemia; treatment; adolescents; Croatia

Sažetak
Therapeutic outcome in children with acute lymphoblastic leukemia (ALL) has greatly improved with more intensive chemotherapy, risk adapted strategies and better supportive care. Aim was analysis of therapeutic results recorded by the National Group for Pediatric Hematology in children with ALL in Croatia treated with pediatric trial ALL IC-BFM 2002. Patients and methods: From November 1, 2002 until November 2, 2010, 208 ALL children i.e. 119 (58%) male and 89 (42%) female, mean age 75.4 months, were treated according to ALL IC-BFM 2002 protocol: SRG – 74 (35.5%) ; IRG -104 (50.6%) ; and HRG -30 (13.9%), at four Croatian pediatric hematology-oncology centers: Zagreb University Hospital Center 145 (69.7%) ; Split University Hospital – 30 (14.4%) ; Rijeka University Hospital Center – 17 (8.2%) ; Zagreb University Children’s Hospital S.Milosrdnice – 16 (7.7%). The first complete remission (CR) was achieved in 208(100.0%) patients, whereas relapse occured in 23(11.2%), hematologic relapse (BM) in 17(8.2%), meningeal relapse (CNS) in 3(1.4%), hematologic and meningeal relapse (BM and CNS) in 2 (0.97%) and hematologic and testicular relapse (BM and TR) in 1(0.48%). 2 (0.9%) patients dropped out from our records. 16(7.6%) of 206 patients died: 3(1.4%)in the first complete remission, 2(0.9%) after bone marrow transplantation and 11 (5.3%) in relapse. 190(92%) patients have survived to the present ; 72(97.7%) from SRG, 97(91.8%) in IRG and 21(64.7%) from HRG. Secondary tumor disease was not recorded. The 4-year event free survival (EFS) was 88% ; overall free survival (OFS) was 89%. These results were nearly identical to those reported from the leading European centers for the treatment children with ALL. All authors have declared no conflicts of interest.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
108-0000000-0049 - Zloćudne bolesti u djece (Konja, Josip, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Citiraj ovu publikaciju

Konja, Josip; Rajić, Ljubica; Čulić, Srđana; Roganović, Jelena; Bilić, Ernest; Femenić, Ranka: Lasan Trčić, Ružica; Batinić, Drago; Jakovljević, Gordana; Aničić, Mirna
Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia // ESMO Congress 2012 : abstracts, 2013. str. 359-359 (poster, međunarodna recenzija, sažetak, znanstveni)
Konja, J., Rajić, L., Čulić, S., Roganović, J., Bilić, E., Femenić, Ranka: Lasan Trčić, Ružica, Batinić, D., Jakovljević, G. & Aničić, M. (2013) Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia. U: ESMO Congress 2012 : abstracts.
@article{article, year = {2013}, pages = {359-359}, keywords = {acute lymphoblastic leukemia, treatment, adolescents, Croatia}, title = {Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia}, keyword = {acute lymphoblastic leukemia, treatment, adolescents, Croatia} }
@article{article, year = {2013}, pages = {359-359}, keywords = {acute lymphoblastic leukemia, treatment, adolescents, Croatia}, title = {Improved therapeutic outcome in children with acute lymphoblastic leukemia in Croatia}, keyword = {acute lymphoblastic leukemia, treatment, adolescents, Croatia} }




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