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Pregled bibliografske jedinice broj: 672251

Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation


Roje, Damir; Zekić Tomaš, Sandra; Ćapkun, Vesna; Marušić, Jelana; Rešić, Jasminka; Kuzmić Prusac, Ivana
Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation // Journal of obstetrics and gynaecology research, 40 (2014), 2; 410-417 (međunarodna recenzija, članak, znanstveni)


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Naslov
Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation

Autori
Roje, Damir ; Zekić Tomaš, Sandra ; Ćapkun, Vesna ; Marušić, Jelana ; Rešić, Jasminka ; Kuzmić Prusac, Ivana

Izvornik
Journal of obstetrics and gynaecology research (1341-8076) 40 (2014), 2; 410-417

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
asymmetrical fetal growth; trophoblast apoptosis; idiopathic intrauterine growth retardation

Sažetak
Aim was to investigate whether there is difference in trophoblast apoptosis between infants with asymmetrical idiopathic intrauterine growth retardation (IUGR) and those with symmetrical fetal growth appropriate for gestational age (AGA). METHODS: Data and placentas from 52 singleton term pregnancies with idiopathic IUGR, from which a subgroup of 33 (63.4%) infants with asymmetrical growth and malnutrition was identified using the ponderal index served as a study group. The control group included 60 (86.9%) infants with symmetrical growth, identified by the same criterion among 69 normal singleton pregnancies with AGA. IUGR was defined by birthweight less than the 10th percentile of standard values. Ponderal index value was considered as the measurement of fetal growth proportionality. RESULTS: The proportion of fetal thinness up to ponderal index value was greater in the IUGR group than control (χ2  = 9.2 ; P = 0.002). There was no statistically significant difference in the cytotrophoblast proliferation (t = 0.88 ; P = 0.373), trophoblast expression of the Bcl-2 anti-apoptotic factor (z = 0.66 ; P = 0.505), total trophoblast apoptotic index (t = 0.45 ; P = 0.651), as in cytotrophoblast (t = 0.01 ; P = 0.988) and syncytiotrophoblast apoptotic index (t = 0.34 ; P = 0.730) between the idiopathic asymmetrical IUGR and control group. CONCLUSION: Asymmetry of fetal growth is a result of rather long-term placental nutritive insufficiency in which trophoblasts have a central role. Although being crucial for its functioning, the proliferative and apoptotic trophoblast activity remains unaltered in the placentas from pregnancies with idiopathic IUGR and asymmetrical fetal growth. The results obtained in this study indicate that placental nutritive insufficiency may develop without any deviation in the physiological trophoblast regeneration via apoptosis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
216-0000000-0484 - Dvostruki model ovarijalne kancerogeneze - molekularna i morfološka studija (Tomić, Snježana, MZOS ) ( POIROT)

Ustanove:
KBC Split,
Medicinski fakultet, Split


Citiraj ovu publikaciju:

Roje, Damir; Zekić Tomaš, Sandra; Ćapkun, Vesna; Marušić, Jelana; Rešić, Jasminka; Kuzmić Prusac, Ivana
Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation // Journal of obstetrics and gynaecology research, 40 (2014), 2; 410-417 (međunarodna recenzija, članak, znanstveni)
Roje, D., Zekić Tomaš, S., Ćapkun, V., Marušić, J., Rešić, J. & Kuzmić Prusac, I. (2014) Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation. Journal of obstetrics and gynaecology research, 40 (2), 410-417.
@article{article, year = {2014}, pages = {410-417}, keywords = {asymmetrical fetal growth, trophoblast apoptosis, idiopathic intrauterine growth retardation}, journal = {Journal of obstetrics and gynaecology research}, volume = {40}, number = {2}, issn = {1341-8076}, title = {Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation}, keyword = {asymmetrical fetal growth, trophoblast apoptosis, idiopathic intrauterine growth retardation} }
@article{article, year = {2014}, pages = {410-417}, keywords = {asymmetrical fetal growth, trophoblast apoptosis, idiopathic intrauterine growth retardation}, journal = {Journal of obstetrics and gynaecology research}, volume = {40}, number = {2}, issn = {1341-8076}, title = {Asymmetrical fetal growth is not associated with altered trophoblast apoptotic activity in idiopathic intrauterine growth retardation}, keyword = {asymmetrical fetal growth, trophoblast apoptosis, idiopathic intrauterine growth retardation} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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