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Two rare cases of central nervous system opportunistic mycoses (CROSBI ID 200865)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Mlinarić Missoni, Emilija ; Baršić Bruno Two rare cases of central nervous system opportunistic mycoses // Arhiv za higijenu rada i toksikologiju, 63 (2012), 4; 505-511. doi: 10.2478/10004-1254-63-2012-2241

Podaci o odgovornosti

Mlinarić Missoni, Emilija ; Baršić Bruno

engleski

Two rare cases of central nervous system opportunistic mycoses

This article presents two cases of opportunistic mycoses (OMs) of the central nervous system (CNS) caused by Cryptococcus neoformans and Aspergillus nidulans, respectively. The patients were hospitalised in local hospitals between 2009 and 2011 because of unspecific symptoms (fever, headache, and/or weight lost). Duration of symptoms varied from 4 days to over 2 weeks. The patients were treated with antibiotics and symptomatically. OM was not suspected in any of them. The patients became critically ill with symptoms of CNS involvement and were transferred to the Intensive Care Unit (ICU) of the University Hospital for Infectious diseases (UHID) in Zagreb. None of the patients belonged to the high-risk population for developing OMs. They were not HIV-infected, had no transplantation of bone marrow or solid organ, and were not on severe immunosuppressive chemotherapy. Fungi were isolated from cerebrospinal fluid (CSF) samples and, in one patient, from aspirate of cerebral abscess. Isolation and mycological identification of all fungal isolates and in vitro antifungal susceptibility testing of these isolates were done at the Reference Centre for Mycological Diagnostics of Systemic and Disseminated Infections (RCMDSDI) in Zagreb. The patient with cryptococcal meningitis was treated with amphotericin B and fluconazole and the patient with cerebral aspergilloma with voriconazole.

central nervous system ; oprotunistic mycosis

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Podaci o izdanju

63 (4)

2012.

505-511

objavljeno

0004-1254

10.2478/10004-1254-63-2012-2241

Povezanost rada

nije evidentirano

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