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Feasibility and effectiveness of indicator condition-guided testing for HIV: results from HIDES I (HIV indicator diseases across Europe study) (CROSBI ID 200860)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Sullivan, AK ; Raben, D ; Reekie, J ; Rayment, M ; Mocroft, A ; Esser, S ; Leon, A ; Begovac, Josip ; Brinkman, K ; Zangerle, R et al. Feasibility and effectiveness of indicator condition-guided testing for HIV: results from HIDES I (HIV indicator diseases across Europe study) // PLoS One, 8 (2013), 1; e52845-e52845

Podaci o odgovornosti

Sullivan, AK ; Raben, D ; Reekie, J ; Rayment, M ; Mocroft, A ; Esser, S ; Leon, A ; Begovac, Josip ; Brinkman, K ; Zangerle, R ; Grzeszczuk, A ; Vassilenko, A ; Hadziosmanovic, V ; Krasnov, M ; Sönnerborg, A ; Clumeck, N ; Gatell, J ; Gazzard, B ; Monforte, Ad ; Rockstroh, J ; Lundgren, JD.

engleski

Feasibility and effectiveness of indicator condition-guided testing for HIV: results from HIDES I (HIV indicator diseases across Europe study)

Improved methods for targeting HIV testing among patients most likely to be infected are required ; HIDES I aimed to define the methodology of a European wide study of HIV prevalence in individuals presenting with one of eight indicator conditions/diseases (ID) ; sexually transmitted infection, lymphoma, cervical or anal cancer/dysplasia, herpes zoster, hepatitis B/C, mononucleosis-like illness, unexplained leukocytopenia/thrombocytopenia and seborrheic dermatitis/exanthema, and to identify those with an HIV prevalence of >0.1%, a level determined to be cost effective. A staff questionnaire was performed. From October 2009- February 2011, individuals, not known to be HIV positive, presenting with one of the ID were offered an HIV test ; additional information was collected on previous HIV testing behaviour and recent medical history. A total of 3588 individuals from 16 centres were included. Sixty-six tested positive for HIV, giving an HIV prevalence of 1.8% [95% CI: 1.42-2.34] ; all eight ID exceeded 0.1% prevalence. Of those testing HIV positive, 83% were male, 58% identified as MSM and 9% were injecting drug users. Twenty percent reported previously having potentially HIV-related symptoms and 52% had previously tested HIV negative (median time since last test: 1.58 years) ; which together with the median CD4 count at diagnosis (400 cell/uL) adds weight to this strategy being effective in diagnosing HIV at an earlier stage. A positive test was more likely for non-white individuals, MSM, injecting drug users and those testing in non-Northern regions. HIDES I describes an effective strategy to detect undiagnosed HIV infection. All eight ID fulfilled the >0.1% criterion for cost effectiveness. All individuals presenting to any health care setting with one of these ID should be strongly recommended an HIV test. A strategy is being developed in collaboration with ECDC and WHO Europe to guide the implementation of this novel public health initiative across Europe.

Testing; HIV; HIDES

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Podaci o izdanju

8 (1)

2013.

e52845-e52845

objavljeno

1932-6203

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

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