engleski

ASSOCIATION BETWEEN HLA AND OCCURRENCE OF NEW ONSET DIABETES AFTER TRANSPLANTATION

Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia Aim: To assess connection between various human leukocyte antigens (HLA A, HLA B and HLA DR) and occurrence of new onset diabetes after transplantation (NODAT) in patients who have undergone kidney transplantation from deceased donor. Methods: Data was collected from patient’s medical charts and statistically analyzed using SPSS. There were 64 examinees (39 males, 25 females ; median age 50 yrs). Results: Prevalence of NODAT in the examined population was 7 out of 58 patients (12.1%). The majority (25 patients ; 40.3%) of the recipients had 3 HLA mismatches, 16 (25.8%) had 4 and 15 (24.2%) had 2 mismatches with their kidney donors. We classified kidney graft function into 4 groups, based on the serum creatinine concentration (SCC). In group 1 patients had SCC<130 μmol/L, in group 2 between 130 and 259 μmol/L, in group 3 between 260 and 400 μmol/L and in group 4 SCC was above 400 μmol/L. SCC was observed at release from hospital and then again 3, 6, 12 and 24 months after kidney transplantation. Majority of examinees (n=22 ; 36.7%) at the release from hospital have belonged to the group 2, after 3 months 36 patients (62.1%) were in the group 1 and the same was after 6 months. After 12 months there were 27 examinees (56.3%) in the group 1 and after 24 months we had 16 examinees (55.2%) in the same group. Conclusions: Type of HLA and number of mismatches were not associated with NODAT. NODAT was not associated with kidney graft function.

idney transplantation; HLA; diabetes

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