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Pregled bibliografske jedinice broj: 671559

TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS


Glavaš, Josipa; Sesar, Sanda; Alkhamis, Tamara; Kralik, Kristina; Prlić, Damir; Barbić, Jerko
TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS // The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine
Split, Hrvatska, 2013. str. 309-309 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 671559 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS

Autori
Glavaš, Josipa ; Sesar, Sanda ; Alkhamis, Tamara ; Kralik, Kristina ; Prlić, Damir ; Barbić, Jerko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine / - , 2013, 309-309

ISBN
978-953-57695-0-7

Skup
The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine

Mjesto i datum
Split, Hrvatska, 24-28.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
kidney transplantation; graft function; TLR4

Sažetak
The study included 70 patients with a transplanted kidney and 50 healthy volunteers representing a control group. Median age of the transplanted patients was 53 years (48-58 years). Transplanted patients had been receiving an adjuvant kidney therapy for an average of 4 years (2-6 years). Median time lapse from receiving kidney transplant was 3 years (ranging from 2-5years). The most common chronic kidney disease diagnosis was chronic glomerulonephritis (21 patient ; 32, 8%), followed by a polycystic kidney disease in 7 patients (10, 9%). Detection of gene polymorphism for tlr4 rs4986790 (A896G, D299G) i tlr4 rs4986791 (C1196T, T399I) was conducted using multiplex real-time PCR. Polymorphism detection was performed using LightCycler. Detection of the TLR4 rs4986790 polymorphism revealed a great predominance in the AA-wild type (104 patients, 86.7%), 44 (88%) out of which were from the control group and 60 (85.7%) from the transplanted group. When analysing rs4986791 polymorphism, the largest proportion of patients (99 ; 82.5%) displays a CC-wild type, followed by a CT-heterozygous group (19 ; 15, 8%), while only 2 patients from the tranplanted group (2.9%) showed a TT-mutation. A significant decrease in erythrocytes (Kruskal Wallis test, p=0.037), creatinine clearence (p=0.019) and hemoglobin levels (p=0.009) was observed in the AA-wild type rs4984790 group, while the AG-heterozygous group showed the highest levels of blood glucose. CC-wild type group type rs4986791 shows significantly lower erythrocyte values (p=0.027), creatinine clearance (p=0.030) and hemoglobin levels (p=0.049).

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
219-0000000-3362 - Genski polimorfizam i funkcija bubrežnog presatka (Barbić, Jerko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Kristina Kralik (autor)

Avatar Url Tamara Alkhamis (autor)

Avatar Url Jerko Barbić (autor)

Citiraj ovu publikaciju:

Glavaš, Josipa; Sesar, Sanda; Alkhamis, Tamara; Kralik, Kristina; Prlić, Damir; Barbić, Jerko
TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS // The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine
Split, Hrvatska, 2013. str. 309-309 (poster, međunarodna recenzija, sažetak, znanstveni)
Glavaš, J., Sesar, S., Alkhamis, T., Kralik, K., Prlić, D. & Barbić, J. (2013) TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS. U: The Eighth ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine.
@article{article, author = {Glava\v{s}, Josipa and Sesar, Sanda and Alkhamis, Tamara and Kralik, Kristina and Prli\'{c}, Damir and Barbi\'{c}, Jerko}, year = {2013}, pages = {309-309}, keywords = {kidney transplantation, graft function, TLR4}, isbn = {978-953-57695-0-7}, title = {TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS}, keyword = {kidney transplantation, graft function, TLR4}, publisherplace = {Split, Hrvatska} }
@article{article, author = {Glava\v{s}, Josipa and Sesar, Sanda and Alkhamis, Tamara and Kralik, Kristina and Prli\'{c}, Damir and Barbi\'{c}, Jerko}, year = {2013}, pages = {309-309}, keywords = {kidney transplantation, graft function, TLR4}, isbn = {978-953-57695-0-7}, title = {TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS}, keyword = {kidney transplantation, graft function, TLR4}, publisherplace = {Split, Hrvatska} }




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