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Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet (CROSBI ID 200840)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Višković, Klaudija ; Rutherford, G.W. ; Sudario, G. ; Stemberger, Lorna ; Brnić, Zoran ; Begovac, Josip Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet // Croatian medical journal, 54 (2013), 4; 330-338

Podaci o odgovornosti

Višković, Klaudija ; Rutherford, G.W. ; Sudario, G. ; Stemberger, Lorna ; Brnić, Zoran ; Begovac, Josip

engleski

Ultrasound measurements of carotid intima-media thickness and plaque in HIV-infected patients on the Mediterranean diet

Aim was to evaluate the influence of food habits, specifically adherence to the Mediterranean diet, on carotid intima-media thickness (CIMT) and the presence of plaques in HIV-infected patients taking antiretroviral therapy (ART) and non-HIV-infected participants and to determine if HIV infection contributes independently to subclinical atherosclerosis. We conducted a cross-sectional study of 110 HIV-infected patients on ART and 131 non-HIV-infected participants at the University Hospital for Infectious Diseases in Zagreb, Croatia, from 2009-2011. CIMT measurement and determination of carotid plaque presence was detected by ultrasound. Adherence to the Mediterranean diet was assessed by a 14-point food-item questionnaire. Subclinical atherosclerosis was defined by CIMT≥0.9 mm or ≥1 carotid plaque. In HIV-infected patients, subclinical atherosclerosis was associated with older age (Plt ; 0.001 ; Mann-Whitney test), higher body mass index (P=0.051 ; Mann-Whitney test), hypertension (Plt ; 0.001 ; χ(2) test), and a lower Mediterranean diet score (P=0.035 ; Mann-Whitney test), and in non-HIV-infected participants with older age (P lt ;  0.001 ; Mann-Whitney test) and hypertension (P=0.006 ; χ(2) test). Multivariate analysis showed that decreased adherence to the Mediterranean diet was associated with higher odds of subclinical atherosclerosis (odds ratio [OR] 2.28, 95% confidence interval [CI] 1.10-4.72, P=0.027) as was current smoking (OR 2.86, 95% CI 1.28-6.40), hypertension (OR 3.04, 95% CI 1.41-6.57), and male sex (OR 2.35, 95% CI 0.97-5.70). There was a significant interaction of age and HIV status, suggesting that older HIV-infected patients had higher odds of subclinical atherosclerosis than controls (OR 3.28, 95% CI 1.24-8.71, P=0.017 at the age of 60 years). We confirmed the association between lower adherence to the Mediterranean diet and increased risk of subclinical atherosclerosis and found that treated HIV infection was a risk factor for subclinical atherosclerosis in older individuals.

Mediterranean diet; carotid intima-media thickness; HIV

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Podaci o izdanju

54 (4)

2013.

330-338

objavljeno

0353-9504

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
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