Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial (CROSBI ID 200824)
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Podaci o odgovornosti
Rimoin, A.W. ; Hoff, N.A. ; Fischer Walker, C.L. ; Hamza, H.S. ; Vince, Adriana ; Abdel Rahman, N. ; Andrašević, Saša ; Emam, S. ; Vukelić, Dalibor ; Elminawi, N. ; Abdel Ghafar, H. ; da Cunha, A.L. ; Qazi, S. ; Gardovska, D. ; Steinhoff, M.C.
engleski
Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial
Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A β -hemolytic streptococcal (GAS) pharyngitis. To assess noninferiority of oral amoxicillin to intramuscular benzathine penicillin G (IM BPG). Children (2 to 12 years) meeting enrollment criteria were randomized 1:1 to receive antibiotic treatment in 2 urban outpatient clinics in Egypt and Croatia. A total of 558 children (Croatia = 166, Egypt = 392) were randomized, with 368 evaluable in an intention-to-treat (ITT) analysis, and 272 evaluable in the per protocol (PP) analysis. In Croatia, ITT and PP treatment success rates were comparable for IM BPG and amoxicillin (2.5% difference vs 1.1% difference, respectively). In Egypt, amoxicillin was not comparable with IM BPG in ITT analysis (15.1% difference), but was comparable in PP analysis (-9.3% difference). If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.
treatment; streptococcal pharyngitis; amoxicillin; benzathine penicillin G
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti