Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey (CROSBI ID 200610)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sóki, J. ; Eitel, Z. ; Urbán, E. ; Nagy, E. ; Piérard, D. ; Glupczynski, Y. ; Nonhoff, C. ; Ieven, M. ; Kalenić, S. ; Chmelařova, E. ; Können, E. ; Calvet, L. ; Dubreuil, L. ; Dósa, E. ; Papaparaskevas, J. ; Szikra, L. ; Miszti, C. ; Terhes, G. ; Mazzariol, A. ; Vila, J. ; Hedberg, M. ; Degener, J. ; Wildeboer-Veloo, L. ; Güler, N. ; Güner, S. ; Ulger, N.
engleski
Molecular analysis of the carbapenem and metronidazole resistance mechanisms of Bacteroides strains reported in a Europe-wide antibiotic resistance survey
Here we examine the carbapenem and metronidazole resistance mechanisms of 640 Bacteroides strains reported in the 2008-2009 European antibiotic susceptibility survey. Of the 22 strains with elevated imipenem minimum inhibitory concentrations (≥4 μg/mL), 10 were cfiA-positive and out of these 5 carried activating insertion sequence (IS) elements in the upstream regions of the cfiA genes. However, resistant strains with cfiA genes but with no activating IS elements were found (n=2) as well as a resistant strain with no cfiA gene. In the former the resistance phenotypes by Etest were heterogeneous, whilst in the latter no carbapenemase production was seen ; both mechanisms have been rarely observed, examined and characterised. Interestingly, few (n=3) nim-positive strains were found, including one metronidazole-resistant strain harbouring nimE activated by ISBf6, and two susceptible strains harbouring chromosomally located nim genes.
molecular analysis; carbapenem; metronidazole; resistance mechanisms; bacteroides strains; resistance survey
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Podaci o izdanju
41 (2)
2013.
122-125
objavljeno
0924-8579
10.1016/j.ijantimicag.2012.10.001
Povezanost rada
Kliničke medicinske znanosti