Chemoreceptor threshold for the start of involuntary breathing movements during maximal apnea (CROSBI ID 383068)
Ocjenski rad | doktorska disertacija
Podaci o odgovornosti
Mihajlo Lojpur
Prof. dr. Željko Dujić
engleski
Chemoreceptor threshold for the start of involuntary breathing movements during maximal apnea
The growing urge to breathe that occurs during breath-holding results in development of involuntary breathing movements (IBMs). The present study determined whether IBMs are initiated at critical levels of hypercapnia and/or hypoxia during maximal apnoea. Arterial blood gasses at the onset of IBM were monitored during maximal voluntary breath-holds. Eleven healthy men performed breath holds after breathing air, hyperoxic–normocapnia, hypoxic–normocapnia, and normoxic–hypercapnia. Prebreathing of the gas mixtures facilitated the IBM onset, reducing the time-to-onset for ~46% (hyperoxic condition) and for ~80% (hypoxic condition) compared to the normoxic air breathing time. A strong correlation (R = 0.83, P = 0.002) between arterial partial pressure of CO2 (PaCO2 ) at IBM onset after pre-breathing hyperoxic and hypercapnic gas mixtures was observed, suggesting the existence of a possible IBM PaCO2 threshold level of ~6.5 ± 0.5 kPa. No clear “threshold” was observed for partial pressure of arterial O2 (PaO2 ). However, we observed that IBM onset was influenced, in part, by an interaction between PaO2 and PaCO2 levels during maximal apnoea. This study demonstrated the complex interaction between arterial blood-gases and the physiological response to maximal breath holding.
Breath holding; arterial blood gases; hemodynamics
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Podaci o izdanju
49
15.07.2013.
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Podaci o ustanovi koja je dodijelila akademski stupanj
Medicinski fakultet u Splitu
Split