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Pregled bibliografske jedinice broj: 670221

Hypercoagulable state in Cushing's syndrome is reversible following remission.


Kaštelan, Darko; Dušek, Tina; Kraljević, Ivana; Aganović, Izet.
Hypercoagulable state in Cushing's syndrome is reversible following remission. // Clinical endocrinology, 78 (2013), 1; 102-106 doi:10.1111/j.1365-2265.2012.04479.x (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 670221 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Hypercoagulable state in Cushing's syndrome is reversible following remission.

Autori
Kaštelan, Darko ; Dušek, Tina ; Kraljević, Ivana ; Aganović, Izet.

Izvornik
Clinical endocrinology (0300-0664) 78 (2013), 1; 102-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Cushing's syndrome; coagulation; thromboembolism

Sažetak
Hypercoagulability is a commonly described complication in patients with Cushing's syndrome (CS). The aim of this study was to assess the long-term effects of surgical remission from CS on serum levels of coagulation and fibrinolytic markers. Eighteen patients with active CS (16 women, 2 men ; age: 38.6 ± 13.7 years) were enrolled in the study. We measured serum levels of coagulation and fibrinolytic markers during active CS and 6 months after remission. The control group comprised 18 age- and sex-matched healthy individuals. Six months after remission from CS, patients had lower levels of factors II (P < 0.001), V (P = 0.02), XI (P = 0.04) and XII (P < 0.001), protein C (P < 0.001), protein S (P = 0.002), antithrombin (P = 0.03), antithrombin Ag (P = 0.008), plasminogen (P = 0.03) and C1 inhibitor (P = 0.001), and aPTT was longer than at enrollment (P = 0.001). Levels of PAI-1 and factors VII, VIII and IX tended to normalize, but there were no significant differences in these parameters before and after surgery, nor were differences found in haemostatic and fibrinolytic markers between the patients in remission and control individuals, except for factor XII (P = 0.02) and protein C (P = 0.004), which were lower among patients in remission.Six months after remission from CS, patients' risk of thromboembolism is comparable to that of healthy individuals.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
108-0000000-3496 - Incidentalomi nadbubrežne žlijezde kao uzrok metaboličkog sindroma (Kaštelan, Darko, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Tina Dušek (autor)

Avatar Url Darko Kaštelan (autor)

Avatar Url Izet Aganović (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Kaštelan, Darko; Dušek, Tina; Kraljević, Ivana; Aganović, Izet.
Hypercoagulable state in Cushing's syndrome is reversible following remission. // Clinical endocrinology, 78 (2013), 1; 102-106 doi:10.1111/j.1365-2265.2012.04479.x (međunarodna recenzija, članak, znanstveni)
Kaštelan, D., Dušek, T., Kraljević, I. & Aganović, I. (2013) Hypercoagulable state in Cushing's syndrome is reversible following remission.. Clinical endocrinology, 78 (1), 102-106 doi:10.1111/j.1365-2265.2012.04479.x.
@article{article, year = {2013}, pages = {102-106}, DOI = {10.1111/j.1365-2265.2012.04479.x}, keywords = {Cushing's syndrome, coagulation, thromboembolism}, journal = {Clinical endocrinology}, doi = {10.1111/j.1365-2265.2012.04479.x}, volume = {78}, number = {1}, issn = {0300-0664}, title = {Hypercoagulable state in Cushing's syndrome is reversible following remission.}, keyword = {Cushing's syndrome, coagulation, thromboembolism} }
@article{article, year = {2013}, pages = {102-106}, DOI = {10.1111/j.1365-2265.2012.04479.x}, keywords = {Cushing's syndrome, coagulation, thromboembolism}, journal = {Clinical endocrinology}, doi = {10.1111/j.1365-2265.2012.04479.x}, volume = {78}, number = {1}, issn = {0300-0664}, title = {Hypercoagulable state in Cushing's syndrome is reversible following remission.}, keyword = {Cushing's syndrome, coagulation, thromboembolism} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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